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    TAK-593
    TAK-593

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4585
    CAS #: 1005780-62-0Purity ≥98%

    Description: TAK-593 is a novel, orally bioavailable and potent small-molecule receptor of VEGFR and PDGFR with IC50s of 3.2, 0.95, 1.1, 4.3 and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα and PDFGRβ, respectively. TAK-593 has potential antineoplastic activity. TAK-593 selectively binds to and inhibits VEGFR and PDGFR, which may result in the inhibition of angiogenesis and tumor cell proliferation.

    References: Bioorg Med Chem. 2013 Apr 15;21(8):2333-2345.Cancer Sci. 2013 Apr;104(4):486-94.


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    TAK-593

    Name: TAK-593
    CAS#: 1005780-62-0
    Chemical Formula: C23H23N7O3
    Exact Mass: 445.18624
    Molecular Weight: 445.47382
    Elemental Analysis: C, 62.01; H, 5.20; N, 22.01; O, 10.77
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: TAK-593, TAK593, TAK 593
    IUPAC/Chemical Name: N-(5-((2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl)oxy)-2-methylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
    InChi Key: DZFZXPPHBWCXPQ-UHFFFAOYSA-N
    InChi Code: InChI=1S/C23H23N7O3/c1-13-4-7-16(11-17(13)24-23(32)18-10-14(2)27-29(18)3)33-21-9-8-20-25-19(12-30(20)28-21)26-22(31)15-5-6-15/h4,7-12,15H,5-6H2,1-3H3,(H,24,32)(H,26,31)
    SMILES Code: O=C(C1=CC(C)=NN1C)NC2=CC(OC3=NN4C(C=C3)=NC(NC(C5CC5)=O)=C4)=CC=C2C


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