My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Sumatriptan Succinate (GR43175)
    Sumatriptan Succinate (GR43175)

    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V0988
    CAS #: 103628-48-4Purity ≥98%

    Description: Sumatriptan Succinate (GR-43175; GR43175; Sumatran; Sumax), an approved triptan sulfa drug and a sulfonamide compound, is a selective 5-HT1 receptor agonist used for the treatment of migraine headaches. It has specificity for 5-HT1D, 5-HT1B and 5-HT1A. Sumatriptan Succinate is the succinate salt of sumatriptan.

    References: Eur J Pharmacol. 1989 Apr 12;163(1):133-6; Br J Pharmacol. 2002 Dec;137(8):1287-97.

    Related CAS #: 103628-48-4 (succinate); 103628-46-2 (free); 143675-45-0 (hemisulfate) 

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)413.49 
    CAS No.103628-48-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (200.7 mM) 
    Water: <1 mg/mL
    Ethanol: 83 mg/mL (200.7 mM) 
    Other info

    Chemical Name: 1-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinate

    SMILES Code: O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O.O=C(O)CCC(O)=O

    SynonymsGR 43175; Sumatriptan; GR-43175; GR43175; Sumatran; Sumax

    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      • V1
      • C2
      • V2
    In Vitro

    In vitro activity: Sumatriptan displays the highest affinity for 5-HT1D (Ki = 17 nM) and 5-HT1B (Ki = 27 nM) binding sites and is slightly less potent at 5-HT1A binding sites (Ki = 100 nM). Sumatriptan markedly attenuates plasma protein extravasation induced by electrical trigeminal ganglion stimulation. Sumatriptan reduces morphological changes in post-capillary venules and mast cells within dura mater following electrical trigeminal ganglion stimulation.

    In VivoSumatriptan at a clinically relevant dose (100 mg/kg, s.c.) leads to a significant reduction of the mechanical allodynia-like behaviour on both the injured and the contralateral sides (peak-effects 6.3 g and 4.4 g, respectively) in a rat model of trigeminal neuropathic pain. Sumatriptan reduces the numbers of Fos-positive cells found in laminae I and IIo of the trigeminal nucleus caudalis and C2 (6, 13 cells and 9 cells, respectively) after mechanical stimulation in cats. Sumatriptan constricts selectively the cranial vessels that are distended and inflamed during migraine, the action is mediated by activation of a 5-HT1 receptor subtype which has been shown in animals to be localized in cranial vessels. Sumatriptan results in oral bioavailabilities of 37, 58 and 23% in rat, dog and rabbit, respectively. sumatriptan is cleared rapidly by metabolic and renal clearance with a half-life of 1-2 hour in rat, dog and rabbit. Sumatriptan produces few adverse pharmacodynamic effects when administered acutely, except at high doses, although it is less well tolerated in dogs. 
    Animal model
    Formulation & Dosage

    Eur J Pharmacol. 1989 Apr 12;163(1):133-6; Br J Pharmacol. 2002 Dec;137(8):1287-97. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Sumatriptan Succinate
    Time-course curves of the effects of various doses of sumatriptan or saline on the mechanical response thresholds in the infraorbital nerve territory ipsilateral and contralateral to the ligature. Br J Pharmacol. 2002 Dec;137(8):1287-97.
    Sumatriptan Succinate
    Br J Pharmacol. 2002 Dec;137(8):1287-97.


      Home Prev Next Last page / pices


      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      Do you confirm the receipt?