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    InvivoChem Cat #: V0850
    CAS #: 651-06-9Purity ≥98%

    Description: Sulfameter (Bayrena; Sulfametoxydiazine; 5-Methoxysulfadiazine; NSC-683528; I-2586; SH-613) is a novel, long-acting sulfonamide antibacterial agent used as a leprostatic agent and also is used to treat UTIs/urinary tract infections. Sulfonamide antibiotics act by blocking the synthesis of dihydrofolic acid via inhibiting the enzyme DHPS/ dihydropteroate synthase. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. The mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. 

    References: Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3; Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4.

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    Molecular Weight (MW)280.3
    CAS No.651-06-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 56 mg/mL (199.8 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide


    InChi Code: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

    SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NC=C(OC)C=N2)=O           


    NSC-683528; Sulfameter; I-2586; I 2586; NSC683528; I2586; SH 613; Sulfametoxipirimidine; Solfametossidiazina [DCIT]; NSC 683528; 

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    In Vitro

    In vitro activity: Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections. Six physically healthy patients each were given 2 g of sulfameter simultaneously with a high lipid, high protein and high carbohydrate test meal. This experiment was designed as a threefold crossover study, and there was a randomized assignment of patients to the different conditions. The results show that sulfameter is significantly better absorbed when administered with a high lipid meal than when given with a high protein or high carbohydrate meal, demonstrated by the areas under the serum concentration curves (AUC), by the peak serum concentration and by the cumulative renal excretion.

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    Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3; Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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