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    Spironolactone (SC9420)
    Spironolactone (SC9420)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1770
    CAS #: 52-01-7Purity ≥98%

    Description: Spironolactone (SC9420; SC-9420; SC 9420; Spiresis; Spiridon) is a potent androgen receptor/AR antagonist with potential antineoplastic activity. It inhibits AR with an IC50 of 77 nM. Spironolactone has been approved for the treatment of fluid build-up caused by heart failure, liver scarring, or kidney disease. It can also be used to treat high blood pressure, low blood potassium that does not improve with supplementation, early puberty, excessive hair growth in women, and as a component of hormone replacement therapy for trans women. 

    References: J Biol Chem. 2010 Sep 24;285(39):29932-40; Mol Cell Endocrinol. 1974 Dec;2(1):59-67.

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    Molecular Weight (MW)416.57
    FormulaC24H32O4S 
    CAS No.52-01-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (199.2 mM)
    Water: <1 mg/mL
    Ethanol: 20 mg/mL (48.0 mM)
    Other info

    Chemical Name: S-((7R,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate

    InChi Key: LXMSZDCAJNLERA-NMFLDQOASA-N

    InChi Code: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24-/m0/s1

    SMILES Code: O=C(O1)CC[[email protected]]12CC[[email protected]@]3([H])[[email protected]]4([H])[[email protected]](SC(C)=O)CC5=CC(CC[[email protected]]5(C)[[email protected]@]4([H])CC[[email protected]]23C)=O

    Synonyms

    SC9420; SC9420; SC-9420; Spiresis; Spiridon


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    In Vitro

    In vitro activity: Spironolactone is a strong AR antagonist (IC50 ~ 77 nM), a weak GR antagonist (IC50 ~ 2.4 μM), and a weak PR agonist (EC50 ~ 740 nM). Spironolactone inhibits androstanolone binding in rat prostate nuclei and androstanolone specific binding in rat prostate cytosol.

    In VivoSpironolactone (1 mg/day) exerts anti-androgenic activity in rats. A single pretreatment of spironolactone (1 mg/rat) inhibits specific and saturable uptake of hormone into prostate induced by tracer dose administration of [3H]testosterone. 
    Animal modelRats
    Formulation & Dosage1 mg/day
    References

    J Biol Chem. 2010 Sep 24;285(39):29932-40; Mol Cell Endocrinol. 1974 Dec;2(1):59-67.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Spironolactone

    Natriuretic in vivo activity of BR-4628 and spironolactone in conscious rats. J Biol Chem. 2010 Sep 24;285(39):29932-40.



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