| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Secoisolariciresinol diglucoside (1-500 μM) exhibits great reducing capacity and good free radical scavenging activity towards hydroxyl, peroxyl radicals and DPPH free radicals [1]. Secoisolariciresinol diglucoside (1-50 μM; 24 hours) attenuates human monocyte adherence and migration to human brain endothelial monolayers [2].
|
|---|---|
| ln Vivo |
In neuroinflammation, a single oral dose of 4 mg/mouse of secoisolariciresinol diglucoside decreases leukocyte adherence and migration across the blood-brain barrier (BBB) [2].
|
| Animal Protocol |
Animal/Disease Models: Hand-fed mice (10 weeks old, male) were injected with TNFα[2].
Doses: 4 mg/mouse. Route of Administration: Po 2 hrs (hrs (hours)) before injection of TNFα. Experimental Results: The adhesion between leukocytes and endothelium was weakened by 50% and the penetration of leukocytes was weakened. Migration across the BBB increased by 64%. |
| References |
|
| Molecular Formula |
C32H46O16
|
|---|---|
| Molecular Weight |
686.698051929474
|
| Exact Mass |
686.278
|
| CAS # |
257930-74-8
|
| Related CAS # |
Secoisolariciresinol;29388-59-8;(R,R)-Secoisolariciresinol diglucoside;158932-33-3;Secoisolariciresinol Monoglucoside;63320-67-2
|
| PubChem CID |
72189390
|
| Appearance |
White to off-white solid powder
|
| LogP |
-0.7
|
| Hydrogen Bond Donor Count |
10
|
| Hydrogen Bond Acceptor Count |
16
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
48
|
| Complexity |
861
|
| Defined Atom Stereocenter Count |
12
|
| SMILES |
O([C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)C[C@@H](CC1C=CC(=C(C=1)OC)O)[C@H](CC1C=CC(=C(C=1)OC)O)CO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O
|
| InChi Key |
SBVBJPHMDABKJV-NNSPVXBOSA-N
|
| InChi Code |
InChI=1S/C32H46O16/c1-43-21-9-15(3-5-19(21)35)7-17(13-45-31-29(41)27(39)25(37)23(11-33)47-31)18(8-16-4-6-20(36)22(10-16)44-2)14-46-32-30(42)28(40)26(38)24(12-34)48-32/h3-6,9-10,17-18,23-42H,7-8,11-14H2,1-2H3/t17-,18-,23-,24-,25-,26-,27+,28+,29-,30-,31-,32-/m1/s1
|
| Chemical Name |
(2R,3R,4S,5S,6R)-2-[(2S,3S)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~145.62 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (72.81 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4562 mL | 7.2812 mL | 14.5624 mL | |
| 5 mM | 0.2912 mL | 1.4562 mL | 2.9125 mL | |
| 10 mM | 0.1456 mL | 0.7281 mL | 1.4562 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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