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Purity: ≥98%
SB-3CT (SB 3CT) is a non-selective and covalent inhibitor of gelatinases and matrix metalloproteinase (MMP) that may have anti-tumor effects. With a Ki of 13.9 nM and 600 nM, respectively, it inhibits the activity of gelatinases A (MMP-2) and B (MMP-9). Gelatinases A and B, which hydrolyze extracellular matrix, have a role in angiogenesis and tumor metastasis.
| Targets |
MMP-2 (Ki = 13.9 nM); MMP-9 (Ki = 600 nM)
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| ln Vitro |
(R)-MG-132, the stereoisomer of MG-132, is being investigated as a possible inhibitor of the proteasome's ability to hydrolyze peptidylglutamyl peptide, trypsin, and chymotrypsin-like activities[1]. The effects of MG-132 and (R)-MG-132 on the inhibition of trypsin-like (TL), peptidylglutamyl peptide hydrolyzing (PGPH), and ChTL of purified 20S proteasomes isolated from human erythrocytes are being studied. MG-132 has IC₅₀ values of 0.89 μM, 104.43 μM, and 5.7 μM for ChTL, TL, and PGPH, in that order. The IC₅₀ values for ChTL, TL, and PGPH of (R)-MG-132 are 0.22 μM, 34.4 μM, and 2.95 μM, respectively[1].
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| ln Vivo |
SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) prevents the intraosseous growth of human PC3 cells in the marrow of human fetal femur fragments that have been implanted in SCID mice[3].
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| Enzyme Assay |
The fluorescence quenched substrate MOCAcPLGLA2pr(Dnp)-AR-NH2 is used to measure the enzymatic activity of MMP-2, MMP-9, and MMP-7. Using a PTI spectrofluorometer, fluorescence is measured. The temperature of the cuvette compartment is set to 25 °C.
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| Cell Assay |
The drug was applied to the cells for a full day at the specified concentration.
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| Animal Protocol |
Five-week-old male C.B.-17.SCID mice[3]
50 mg/kg IP; every other day; five weeks |
| References |
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| Molecular Formula |
C15H14O3S2
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| Molecular Weight |
306.40
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| Exact Mass |
306.04
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| Elemental Analysis |
C, 58.80; H, 4.61; O, 15.67; S, 20.93
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| CAS # |
292605-14-2
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| Related CAS # |
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| Appearance |
Solid powder
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| SMILES |
C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3
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| InChi Key |
LSONWRHLFZYHIN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
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| Chemical Name |
2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane
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| Synonyms |
SB3CT; SB3-CT; SB-3CT
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2637 mL | 16.3185 mL | 32.6371 mL | |
| 5 mM | 0.6527 mL | 3.2637 mL | 6.5274 mL | |
| 10 mM | 0.3264 mL | 1.6319 mL | 3.2637 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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