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    SB-3CT
    SB-3CT

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0740
    CAS #: 292605-14-2Purity ≥98%

    Description: SB-3CT is a novel, potent, effective and selective gelatinases/matrix metalloproteinase (MMP) inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. 

    References: Cancer Res. 2005 May 1;65(9):3523-6.

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    Molecular Weight (MW)306.40
    FormulaC15H14O3S2
    CAS No.292605-14-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 61 mg/mL (199.1 mM)
    Water: <1 mg/mL
    Ethanol: 10 mg/mL (32.6 mM)
    Solubility (In vivo)4% DMSO+corn oil: 10 mg/mL
    SynonymsSB3CT; SB3-CT; SB-3CT; 

    Chemical Name: 2-(((4-phenoxyphenyl)sulfonyl)methyl)thiirane

    InChi Key: LSONWRHLFZYHIN-UHFFFAOYSA-N

    InChi Code: InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2

    SMILES Code: O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O


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    In Vitro

    In vitro activity: SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.


    Cell Assay: PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted. 

    In VivoIn L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.
    Animal modelMouse L-CI.5s T-cell lymphoma model
    Formulation & DosageDissolved in 10% DMSO.; 50 mg/kg; i.p. injection
    ReferencesCancer Res. 2005 May 1;65(9):3523-6; Int J Cancer. 2006 Jun 1;118(11):2721-6.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    SB-3CT

    Inhibition of T-cell lymphoma liver metastasis by SB-3CT. Cancer Res. 2005 May 1;65(9):3523-6.
     

    SB-3CT

    Morphologic appearance and size of T-cell lymphoma metastatic foci of livers from SB-3CT–treated and control mice. Cancer Res. 2005 May 1;65(9):3523-6.
     

    SB-3CT

    In situ zymography with DQ gelatin. Cancer Res. 2005 May 1;65(9):3523-6.
     

    SB-3CT

    Survival of control and SB-3CT–treated mice. Cancer Res. 2005 May 1;65(9):3523-6.



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