| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg | |||
| 250mg | |||
| 500mg | |||
| Other Sizes |
| Targets |
This saponin targets multiple pathways involved in inflammation, oxidative stress, cancer, and thrombosis. Its anti-inflammatory activity suggests modulation of inflammatory mediators and immune cell function. Its antioxidant activity indicates free radical scavenging and protection against oxidative damage. Its antitumor effects suggest inhibition of cancer cell proliferation and survival. Its anti-thrombotic activity involves effects on coagulation pathways. The compound's ability to induce autophagy suggests effects on cellular homeostasis and survival. Its protective roles in cardiovascular and metabolic research models indicate effects on heart function and metabolism.
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| ln Vitro |
In vitro, Saponin C from Liriope muscari has demonstrated anti-inflammatory, antioxidant, and antitumor activities. It induces autophagy. It has anti-thrombotic activity. Its protective effects in cardiovascular and metabolic models have been demonstrated. These activities confirm its potential for research on inflammation, oxidative stress, cancer, thrombosis, and metabolic diseases. Detailed in vitro studies are described in the primary literature.
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| ln Vivo |
In vivo, Saponin C from Liriope muscari has been studied for its anti-inflammatory, antioxidant, and antitumor effects, as well as its protective roles in cardiovascular and metabolic research models. Its anti-thrombotic activity has been demonstrated. However, detailed in vivo efficacy and safety data are described in the primary literature. The compound is primarily used in research applications. Further studies are needed to fully characterize its in vivo biological activity and therapeutic potential. The compound is intended for research use only.
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| Enzyme Assay |
For in vitro biochemical assays, Saponin C from Liriope muscari is evaluated for its antioxidant, anti-inflammatory, and enzyme inhibitory activities. Antioxidant activity is measured using DPPH, ABTS, or FRAP assays. Anti-inflammatory activity is assessed by measuring inhibition of inflammatory mediators. Enzyme inhibition studies can be performed to evaluate effects on specific targets. Autophagy induction is assessed by measuring LC3-II conversion and p62 levels. These cell-free and cell-based assays help characterize the compound's multiple biological activities.
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| Cell Assay |
In vitro cellular assays for Saponin C from Liriope muscari are performed using various cell types including immune cells, cancer cells, and cardiovascular cells. Cells are cultured in standard media and treated with the compound at various concentrations. Anti-inflammatory activity is assessed by measuring cytokine production. Antioxidant activity is assessed by measuring ROS levels. Anticancer activity is assessed using cell viability, proliferation, and apoptosis assays. Autophagy is assessed by measuring LC3-II conversion and p62 levels. These cellular assays help validate the compound's multiple biological activities.
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| Animal Protocol |
In vivo animal experiments with Saponin C from Liriope muscari are conducted in models of inflammation, cancer, thrombosis, and cardiovascular diseases. The compound is administered via oral gavage, intraperitoneal injection, or intravenous injection. Efficacy endpoints depend on the specific disease model and could include inflammation reduction, tumor growth inhibition, thrombus formation, or improvement in cardiac function. Researchers should consult the primary literature for any available in vivo protocols and data.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Saponin C from Liriope muscari are not extensively documented. As a large steroidal saponin with a molecular weight of 871.02, it is expected to have limited oral bioavailability. The compound may be metabolized by intestinal microbiota. Detailed PK parameters such as half-life, Cmax, Tmax, AUC, and protein binding are not available in the literature. The compound should be stored at -20°C.
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| Toxicity/Toxicokinetics |
The toxicological profile of Saponin C from Liriope muscari is not extensively characterized. As a natural steroidal saponin from Liriope muscari, it is generally considered to have a moderate safety profile, but comprehensive toxicity studies are limited. The compound is intended for research use only and not for human therapeutic applications. Researchers should follow standard laboratory safety practices when handling this compound.
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| Additional Infomation |
This saponin is a valuable research tool for studying anti-inflammatory, antioxidant, antitumor, and anti-thrombotic mechanisms. Its protective roles in cardiovascular and metabolic research models make it relevant for studying heart disease and metabolism. Its ability to induce autophagy provides opportunities for studying autophagy regulation. As a major active component of Liriope muscari, it is also important for natural product chemistry and the quality control of herbal medicines.
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| Molecular Formula |
C11H16N5O2+
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|---|---|
| Molecular Weight |
250.27704
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| Exact Mass |
870.461
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| CAS # |
130551-41-6
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| PubChem CID |
11007422
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| Appearance |
White to yellow solid
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| Density |
1.4±0.1 g/cm3
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| Melting Point |
292-295℃
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| Index of Refraction |
1.627
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| LogP |
2.6
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| Hydrogen Bond Donor Count |
9
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| Hydrogen Bond Acceptor Count |
17
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
61
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| Complexity |
1600
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| Defined Atom Stereocenter Count |
26
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| SMILES |
C[C@@H]1CC[C@@]2([C@@H](C)[C@H]3[C@H](C[C@H]4[C@@H]5CC=C6C[C@H](C[C@H]([C@]6(C)[C@H]5CC[C@@]43C)O[C@H]7[C@@H]([C@H]([C@H]([C@@H](C)O7)O)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O[C@H]9[C@@H]([C@H]([C@@H]([C@@H](CO)O9)O)O)O)O)O2)OC1
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| InChi Key |
XTGHTMMHUVFPBQ-ZUTFNMMGSA-N
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| InChi Code |
InChI=1S/C44H70O17/c1-18-8-11-44(55-16-18)19(2)30-27(61-44)14-25-23-7-6-21-12-22(46)13-29(43(21,5)24(23)9-10-42(25,30)4)58-41-38(60-40-36(53)34(51)33(50)28(15-45)57-40)37(31(48)20(3)56-41)59-39-35(52)32(49)26(47)17-54-39/h6,18-20,22-41,45-53H,7-17H2,1-5H3/t18-,19+,20-,22-,23-,24+,25+,26-,27+,28-,29-,30+,31+,32+,33-,34+,35-,36-,37+,38-,39+,40+,41+,42+,43+,44-/m1/s1
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| Chemical Name |
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-16-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14-yl]oxy-6-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~114.81 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.87 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9955 mL | 19.9776 mL | 39.9553 mL | |
| 5 mM | 0.7991 mL | 3.9955 mL | 7.9911 mL | |
| 10 mM | 0.3996 mL | 1.9978 mL | 3.9955 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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