| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| ln Vitro |
Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum; however, it is inactive against Salmonella marcescens, Pseudomonas aeruginosa, Escherichia coli, Corynebacterium bovis inactive, Corynebacterium striatum, and Corynebacterium jeckii (with a minimum bactericidal concentration (MBC) of 31.3 to 375.0 μg/mL). According to kinetic studies, sapienic acid gradually kills Streptococcus sanguinis and Streptococcus mitis over the course of 24 hours [1].
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|---|---|
| References |
[1]. Fischer CL, et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61.
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| Additional Infomation |
Sapienic acid (HCA) is a Sapienic acid with its double bond located at position 6 (Z-geometric isomer). It is a major component of human sebum and participates in skin self-disinfection and the relief of atopic dermatitis. It possesses antibacterial, anti-psoriatic, and metabolic effects. It is the conjugate acid of HCA.
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| Molecular Formula |
C16H30O2
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|---|---|
| Exact Mass |
254.225
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| CAS # |
17004-51-2
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| Related CAS # |
Sapienic acid sodium;217477-25-3
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| PubChem CID |
5312419
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| Appearance |
Colorless to light yellow solid-liquid Mixture
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| LogP |
5.328
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
18
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| Complexity |
209
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCC/C=C\CCCCC(=O)O
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| InChi Key |
NNNVXFKZMRGJPM-KHPPLWFESA-N
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| InChi Code |
InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h10-11H,2-9,12-15H2,1H3,(H,17,18)/b11-10-
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| Chemical Name |
(Z)-hexadec-6-enoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~200 mg/mL (~786.1 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (19.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (19.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (19.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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