| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g | |||
| 25g | |||
| Other Sizes |
Purity: ≥98%
Salbutamol Sulfate (AH-3365; AH3365; trade name Ventolin among others) is a potent, selective and short-acting β2-adrenergic receptor agonist with the potential to relax airway smooth muscles. It activates the β2-adrenergic receptor with an EC50 of 8.93 µM. Salbutamol is used to treat both chronic obstructive pulmonary disease, or COPD, and asthma. It has higher specificity for pulmonary beta receptors compared to beta1-adrenergic receptors found in the heart because it is 29 times more selective for beta2 receptors than beta1 receptors.
| Targets |
β2-adrenergic receptor ( IC50 = 8930 nM )
β2-adrenoceptor [3] |
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| ln Vitro |
In isolated slow-twitch (soleus) and fast-twitch (extensor digitorum longus, EDL) skeletal muscles of guinea-pigs, Salbutamol Sulfate (AH-3365; Albuterol) (R,S-enantiomer) enhanced the amplitude of incompletely fused tetanic contractions in a concentration-dependent manner. The effect was more potent in slow-twitch muscles: 1 μM increased contraction amplitude by ~25%, while 10 μM produced a ~40% increase. In fast-twitch muscles, 10 μM induced a ~20% increase in contraction amplitude. The R-enantiomer was responsible for the majority of the activity, with the S-enantiomer showing minimal effect at concentrations up to 10 μM [1]
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| ln Vivo |
In young healthy men (18-30 years old), oral administration of Salbutamol Sulfate (AH-3365; Albuterol) (8 mg/day, divided into two doses) for 7 consecutive days significantly increased skeletal muscle strength. It enhanced maximal isometric contraction force of the quadriceps muscle by ~12% and isokinetic contraction torque (at 60°/s) by ~10% compared to placebo. No significant changes in muscle mass were observed [3]
In healthy male subjects, short-term oral administration of Salbutamol Sulfate (AH-3365; Albuterol) (4 mg/day for 4 days) improved exercise endurance. It increased the time to exhaustion during cycle ergometer exercise at 70% maximal oxygen uptake (VO2max) by ~15% and reduced the rate of glycogen depletion in vastus lateralis muscle. Additionally, it increased whole-body fat oxidation during exercise (by ~20%) and decreased carbohydrate oxidation (by ~12%) [2] |
| Animal Protocol |
Guinea-pig skeletal muscle contraction assay: Adult guinea-pigs are sacrificed, and soleus (slow-twitch) and EDL (fast-twitch) muscles are dissected and mounted in organ baths containing oxygenated physiological saline at 37°C. Muscles are stimulated electrically with trains of pulses (20-50 Hz) to produce incompletely fused tetanic contractions. Salbutamol Sulfate (AH-3365; Albuterol) (0.1-10 μM) or its enantiomers are added to the bath, and contraction amplitude is recorded continuously for 30 minutes to assess dose-dependent effects [1]
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| Toxicity/Toxicokinetics |
Effects During Pregnancy and Lactation
◉ Overview of Medication Use During Lactation While there is currently no published data on oral or inhaled salbutamol during lactation, data on the related drug terbutaline suggest that very small amounts are expected to be excreted into breast milk. Authors of multiple reviews and expert guidelines agree that the use of such medications during lactation is acceptable due to the low bioavailability of inhaled bronchodilators and the low maternal serum concentrations after administration. ◉ Effects on Breastfed Infants As of the revision date, no relevant published information was found. ◉ Effects on Lactation and Breast Milk As of the revision date, no relevant published information was found. |
| References |
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| Additional Infomation |
Albuterol sulfate is an ethanolamine sulfate whose function is related to that of salbutamol. Salbutamol sulfate is the sulfate of the short-acting sympathomimetic drug salbutamol. Salbutamol is a 1:1 racemic mixture of (R)-salbutamol and (S)-salbutamol and has a bronchodilatory effect. Salbutamol stimulates β2-adrenergic receptors in the lungs, thereby activating adenylate cyclase, which catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP). Increased cAMP concentration relaxes bronchial smooth muscle, relieves bronchospasm, and reduces the release of inflammatory cellular mediators, especially those from mast cells. Salbutamol has a weaker stimulatory effect on β1-adrenergic receptors, thereby enhancing myocardial contractility and frequency. It is a short-acting β2-adrenergic agonist, primarily used as a bronchodilator to treat asthma. Salbutamol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereoselective preparation method of the R(-) isomer of salbutamol is called L-salbutamol. See also: salbutamol (broad spectrum); salbutamol sulfate; ipratropium bromide (component); salbutamol sulfate; budesonide (one of the components). Salbutamol sulfate (AH-3365; salbutamol) is a selective β2-adrenergic receptor agonist with significant effects on skeletal muscle function [3]. Its mechanism of action involves activating β2-adrenergic receptors in skeletal muscle, leading to increased intracellular cAMP levels, thereby enhancing muscle contractility and regulating energy metabolism (promoting fat oxidation and glycogen conservation) [2][3]. The R-enantiomer (levosalbutamol) is the pharmacologically active form, while the S-enantiomer has negligible β2-adrenergic receptor activity [1]. It exhibits synergistic effects in humans, including improving exercise endurance and enhancing skeletal muscle strength without significantly altering muscle mass [2][3].
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| Molecular Formula |
C13H23NO7S
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|---|---|---|
| Molecular Weight |
337.39
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| Exact Mass |
576.271
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| Elemental Analysis |
C, 46.28; H, 6.87; N, 4.15; O, 33.19; S, 9.50
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| CAS # |
51022-70-9
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| Related CAS # |
Salbutamol; 18559-94-9
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| PubChem CID |
39859
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| Appearance |
White to off-white solid powder
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| Boiling Point |
419.2ºC at 760 mmHg
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| Melting Point |
180 °C
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| Flash Point |
250 °C
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| LogP |
2.124
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| Hydrogen Bond Donor Count |
10
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
39
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| Complexity |
309
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S(=O)(=O)(O[H])O[H].O([H])C([H])(C1C([H])=C([H])C(=C(C([H])([H])O[H])C=1[H])O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H].O([H])C([H])(C1C([H])=C([H])C(=C(C([H])([H])O[H])C=1[H])O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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| InChi Key |
OVICLFZZVQVVFT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
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| Chemical Name |
4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol sulfuric acid salt
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (347.05 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9639 mL | 14.8196 mL | 29.6393 mL | |
| 5 mM | 0.5928 mL | 2.9639 mL | 5.9279 mL | |
| 10 mM | 0.2964 mL | 1.4820 mL | 2.9639 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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