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    Sacubitril hemicalcium
    Sacubitril hemicalcium

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4540
    CAS #: 1369773-39-6Purity ≥98%

    Description: Sacubitril hemicalcium (also known as AHU377; AHU-377; Entresto), the hemicalcium salt of Sacubitril which is a component of the heart failure medicine LCZ696 (sacubitril/valsartan), is a novel and potent NEP (neutral endopeptidase 24.11) inhibitor with an IC50 of 5 nM. It is a prodrug that can be activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

    References: J Med Chem. 1995 May 12;38(10):1689-700.Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.Circ Heart Fail. 2015 Jan;8(1):71-8.

    Related CAS : 1369773-39-6 (hemi-calcium); 149709-62-6 (free acid); 149690-05-1 (sodium); 936623-90-4 (mixture with valsartan); 936623-90-4; 137862-53-4; 149709-44-4 (Sacubitrilat)

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    Sacubitril hemicalcium

    Name: Sacubitril calcium salt
    CAS#: 1369773-39-6 (hemi-calcium)
    Chemical Formula: C48H56CaN2O10
    Molecular Weight: 861.06
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: AHU337; LCZ696; AHU-337; LCZ 696; AHU 337; LCZ696
    Chemical Name: calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
    InChi Key: DDLCKLBRBPYKQS-OXXXZDCLSA-L
    InChi Code: InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;;+2/p-2/t2*17-,21+;/m11./s1
    SMILES Code: O=C(CCC(N[[email protected]](CC1=CC=C(C=C1)C2=CC=CC=C2)C[[email protected]](C(OCC)=O)C)=O)[O-].O=C(CCC(N[[email protected]](CC3=CC=C(C=C3)C4=CC=CC=C4)C[[email protected]](C(OCC)=O)C)=O)[O-].[Ca+2]


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