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    Rocuronium Bromide (ORG 9426 Bromide)
    Rocuronium Bromide (ORG 9426 Bromide)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1176
    CAS #: 119302-91-9Purity ≥98%

    Description: Rocuronium Bromide (ORG-9426;  Zemuron; Esmeron; Esmeron; Esmerone) is a potent and competitive Nicotinic acetyl-choline receptors (AchR) antagonist, which is a non-depolarizing neuromuscular blocking agent used in anaesthesia required for surgery or mechanical ventilation. Rocuronium bromide is an aminosteroid type neuromuscular blocking agent acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell.  

    References: Cytotechnology. 2011 May;63(3):239-45; Vet Ophthalmol. 2011 Jul;14(4):244-7.

    Related CAS #: 119302-91-9 (bromide)   143558-00-3 (cation)

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    Molecular Weight (MW)609.68 
    FormulaC32H53N2O4.Br 
    CAS No.119302-91-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 122 mg/mL (200.1 mM)
    Water: 122 mg/mL (200.1 mM)
    Ethanol: 122 mg/mL (200.1 mM)
    Other info

    Chemical Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;bromide

    InChi Key: OYTJKRAYGYRUJK-UHFFFAOYSA-M

    InChi Code: InChI=1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1

    SMILES Code: CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]

    SynonymsORG9426; Rocuronium Bromide; Zemuron; Rocuronium (Bromide); ORG 9426 ;ORG-9426; Esmeron; UNII-I65MW4OFHZ; Esmeron; Esmerone; 


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    In Vitro

    In vitro activity: Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively.

    In VivoRocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. 
    Animal modelCats
    Formulation & Dosage0.3 mg/kg and 0.6 mg/kg
    References

    Cytotechnology. 2011 May;63(3):239-45; Vet Ophthalmol. 2011 Jul;14(4):244-7. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Rocuronium Bromide

    The effects of rocuronium bromide treatment on cyclooxygenase-1 (COX-1) in calf pulmonary artery endothelial (CPAE) cells. Int Neurourol J. 2016 Dec; 20(4): 296–303.
     

    Rocuronium Bromide

    The effects of rocuronium bromide treatment on cyclooxygenase-2 (COX-2) in calf pulmonary artery endothelial (CPAE) cells. Int Neurourol J. 2016 Dec; 20(4): 296–303.
     

    Rocuronium Bromide

    The effects of rocuronium bromide treatment on endothelial nitric oxide synthase (eNOS) in calf pulmonary artery endothelial (CPAE) cells. Int Neurourol J. 2016 Dec; 20(4): 296–303.


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