Ritodrine HCl (DU21220 HCl)

Alias:
Cat No.:V1118 Purity: ≥98%
Ritodrine HCl (DU21220; DU21220; ST51015115; ST-51015115; Pre-Par; Utopar), the hydrochloride salt of ritodrine, is a β-2 adrenergic receptor agonist used to treat premature labor.
Ritodrine HCl (DU21220 HCl) Chemical Structure CAS No.: 23239-51-2
Product category: Adrenergic Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
100mg
250mg
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1g
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Other Forms of Ritodrine HCl (DU21220 HCl):

  • Ritodrine (DU21220)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Ritodrine HCl (DU21220; DU21220; ST51015115; ST-51015115; Pre-Par; Utopar), the hydrochloride salt of ritodrine, is a β-2 adrenergic receptor agonist used to treat premature labor.

Biological Activity I Assay Protocols (From Reference)
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C17H22CLNO3
Molecular Weight
323.81
Exact Mass
323.13
Elemental Analysis
C, 63.06; H, 6.85; Cl, 10.95; N, 4.33; O, 14.82
CAS #
23239-51-2
Appearance
Solid powder
SMILES
C[C@@H]([C@@H](C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O.Cl
InChi Key
IDLSITKDRVDKRV-XHXSRVRCSA-N
InChi Code
InChI=1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m0./s1
Chemical Name
4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride
Synonyms

DU21220; Ritodrine Hydrochloride; Ritodrine (hydrochloride); (+-)-Ritodrine hydrochloride; DU21220; DU21220; ST51015115; ST-51015115; Pre-Par; Utopar

HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 65~120 mg/mL (200.7~370.6 mM)
Water: ~65 mg/mL (~200.7 mM)
Ethanol: ~65 mg/mL
Solubility (In Vivo)

Chemical Name:4-[2-[[(1S,2R)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride

InChi Key:IDLSITKDRVDKRV-JSUROZADSA-N

InChi Code:InChI=1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m1./s1

SMILES Code:CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O.Cl

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.0882 mL 15.4412 mL 30.8823 mL
5 mM 0.6176 mL 3.0882 mL 6.1765 mL
10 mM 0.3088 mL 1.5441 mL 3.0882 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
  • Enter 350.26 in the Molecular Weight (MW) box
  • Enter 10 in the Concentration box and choose the correct unit (mM)
  • Enter 5 in the Volume box and choose the correct unit (mL)
  • Click the “Calculate” button
  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
  • Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
  • Enter 25 into the Concentration (End) box and select the correct unit (mM)
  • Enter 25 into the Volume (End) box and choose the correct unit (mL)
  • Click the “Calculate” button
  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
  • To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
  • Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

  • Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
  • Click the “Calculate” button
  • The answer appears in the Volume (to add to vial) box
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00679705 Completed Drug: Ritodrine
Drug: Atosiban
Drug: Placebo
Healthy University Hospital, Ghent May 2008 Phase 1
NCT02538718 Completed Drug: MgSO4
Drug: YTP(Ritodrine)
Preterm Labor Seoul National University
Hospital
September 22, 2015 Not Applicable
NCT03040752 Completed Drug: Nifedipine 20 Mg
Drug: Ritodrine Oral Tablet
Preterm Birth Cairo University January 2015 Phase 4
NCT00290173 Completed Drug: efficacy of oral
ritodrine in maintaining
uterine quiescence
Pregnancy University of Zagreb August 2005 Not Applicable
Biological Data
  • Characteristics of Treatment in the Ritodrine and Placebo Groups. N Engl J Med . 1992 Jul 30;327(5):308-12.
  • There were no maternal deaths. There were 48 deaths among the 771 infants (Table 4), including 21 stillbirths (10 in the ritodrine group and 11 in the placebo group). N Engl J Med . 1992 Jul 30;327(5):308-12.
  • At a corrected postnatal age of 18 months, the 246 children born to women in the two groups who were randomly selected to return for follow-up evaluations had similar scores on the Bayley Psychomotor Development Index (ritodrine, 110.9±16.8; placebo, 108.7±15.5). N Engl J Med . 1992 Jul 30;327(5):308-12.
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