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    Riociguat (BAY 63-2521)
    Riociguat (BAY 63-2521)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1868
    CAS #: 625115-55-1 Purity ≥98%

    Description: Riociguat (formerly also known as BAY 63-2521, and BAY 632521) is a novel, potent and oral bioavailable and soluble guanylate cyclase (GC) stimulator that is currently in clinical development. Riociguat is used in the treatment of ipulmonary hypertension. Riociguat is currently in clinical development by Bayer. The Phase III clinical trials investigated the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators.

    References: Eur Respir J. 2008 Oct;32(4):881-91; Br J Pharmacol. 2015 Nov;172(21):5199-210.

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    Molecular Weight (MW) 422.42
    Formula C20H19FN8O2 
    CAS No. 625115-55-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: ≥ 50 mg/mL (118.37 mM)
    Water: <1 mg/mL
    Ethanol: N/A
    Solubility (In vivo)IUPAC/Chemical Name: methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate
    InChi Key: WXXSNCNJFUAIDG-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
    SMILES Code: O=C(OC)N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)C
    SynonymsBAY 63-2521; BAY63-2521; BAY632521; Trade name: Adempas


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    Riociguat (BAY 63-2521)


    Riociguat prevents hyperoxia-ablated vascular development. PLoS One. 2018 Jul 10;13(7):e0199927.

     Riociguat (BAY 63-2521)


    Riociguat decreases hyperoxia-induced vascular remodeling. PLoS One. 2018 Jul 10;13(7):e0199927.

     Riociguat (BAY 63-2521)


    Riociguat reduces and alters hyperoxia-induced lung inflammation. PLoS One. 2018 Jul 10;13(7):e0199927.


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