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    Riociguat (BAY 63-2521)
    Riociguat (BAY 63-2521)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1868
    CAS #: 625115-55-1 Purity ≥98%

    Description: Riociguat (formerly also known as BAY-63-2521, BAY-632521; trade name Adempas) is a first-in-class and oral bioavailable soluble guanylate cyclase (GC) stimulator that has been approved to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators.

    References: Eur Respir J. 2008 Oct;32(4):881-91; Br J Pharmacol. 2015 Nov;172(21):5199-210.

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    Molecular Weight (MW) 422.42
    Formula C20H19FN8O2 
    CAS No. 625115-55-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: ≥ 50 mg/mL (118.37 mM)
    Water: <1 mg/mL
    Ethanol: N/A
    Solubility (In vivo)IUPAC/Chemical Name: methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate
    InChi Key: WXXSNCNJFUAIDG-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
    SMILES Code: O=C(OC)N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)C
    SynonymsBAY 63-2521; BAY63-2521; BAY632521; Trade name: Adempas


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    Riociguat (BAY 63-2521)


    Riociguat prevents hyperoxia-ablated vascular development. PLoS One. 2018 Jul 10;13(7):e0199927.

     Riociguat (BAY 63-2521)


    Riociguat decreases hyperoxia-induced vascular remodeling. PLoS One. 2018 Jul 10;13(7):e0199927.

     Riociguat (BAY 63-2521)


    Riociguat reduces and alters hyperoxia-induced lung inflammation. PLoS One. 2018 Jul 10;13(7):e0199927.


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