| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
|
||
| 250mg |
|
||
| Other Sizes |
|
Purity: ≥98%
Rhamnose (L-Rhamnose) is a naturally occuring methylpentose found in many plant glycosides and some gram-negative bacterial lipopolysaccharides. Rhamnose-conjugated immunogens is used in immunotherapies. Rhamnose crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption.
| References |
Sheridan RT, Hudon J, Hank JA, Sondel PM, Kiessling LL. Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells. Chembiochem. 2014 Jul 7;15(10):1393-8. doi: 10.1002/cbic.201402019. Epub 2014 Jun 6. PubMed PMID: 24909955; PubMed Central PMCID: PMC4205123.
|
|---|---|
| Additional Infomation |
Aldehydo-L-rhamnose is the acyclic form of L-rhamnose. It is a L-rhamnose and an aldehyde.
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal has been reported in Codonopsis pilosula, Poa huecu, and other organisms with data available. A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides. See also: L-Rhamnose (annotation moved to). |
| Molecular Formula |
C6H12O5
|
|---|---|
| Molecular Weight |
164.1565
|
| Exact Mass |
164.068
|
| CAS # |
3615-41-6
|
| Related CAS # |
Rhamnose monohydrate;10030-85-0
|
| PubChem CID |
19233
|
| Appearance |
White to off-white solid powder
|
| Density |
1.6±0.1 g/cm3
|
| Boiling Point |
323.9±42.0 °C at 760 mmHg
|
| Melting Point |
91-95°C
|
| Flash Point |
149.7±27.9 °C
|
| Vapour Pressure |
0.0±1.6 mmHg at 25°C
|
| Index of Refraction |
1.593
|
| LogP |
-0.34
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
11
|
| Complexity |
126
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
C[C@@H]([C@@H]([C@H]([C@H](C=O)O)O)O)O
|
| InChi Key |
PNNNRSAQSRJVSB-BXKVDMCESA-N
|
| InChi Code |
InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h2-6,8-11H,1H3/t3-,4-,5-,6-/m0/s1
|
| Chemical Name |
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal
|
| Synonyms |
L-Rhamnose NSC 2056 NSC-2056 NSC2056 Isodulcitol Isodulcit Locaose L-Mannomethylose
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~609.16 mM)
DMSO : ~100 mg/mL (~609.16 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 50 mg/mL (304.58 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | |
| 5 mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | |
| 10 mM | 0.6092 mL | 3.0458 mL | 6.0916 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01756040 | COMPLETEDWITH RESULTS | Drug: Lactulose -rhamnose solution | Intestinal Permeability Prematurity |
University of Maryland, Baltimore | 2013-02-01 | Phase 1 |
| NCT03962998 | COMPLETED | Drug: Lactulose/Rhamnose solution Drug: MB-102 |
Crohn Disease | MediBeacon | 2019-10-27 | Early Phase 1 |
| NCT02690532 | COMPLETED | Celiac Disease | Mayo Clinic | 2016-03 | ||
| NCT01837940 | COMPLETED | Dietary Supplement: Placebo Dietary Supplement: Lactobacillus reuteri DSM 17938 |
Abdominal Pain Constipation Diarrhea Indigestion Reflux |
Örebro University, Sweden | 2013-04 | Phase 3 |
| NCT03986476 | COMPLETED | Dietary Supplement: Probiotics Other: Placebo |
IBS | Örebro University, Sweden | 2019-03-26 | Not Applicable |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA