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| Additional Infomation |
Pyridoxal phosphate monohydrate is a pyridinecarboxaldehyde. Medicle's MC-1 drug is a cardioprotective agent designed to reduce damage to the heart during arterial blockage and reopening of arteries after bypass surgery. Pyridoxal phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP participates in various enzymatic transamination, decarboxylation, and deamination reactions; it is essential for the synthesis of amino acids and their metabolites, as well as for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate to γ-aminobutyric acid (GABA) and levodopa to dopamine. PLP can be used as a dietary supplement for vitamin B6 deficiency. Low PLP levels in the brain can lead to neurological dysfunction. PLP is the active form of vitamin B6 and acts as a coenzyme in the synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During amino acid transamination, pyridoxal phosphate is transiently converted to pyridoxamine phosphate (pyridoxamine). Drug Indications MC-1 has been investigated for the treatment of coronary artery disease. Mechanism of Action MC-1 is a biologically active natural product and can be considered a chemical entity that has undergone evolutionary selection and validation to bind to specific protein domains. Therefore, its potential structural framework or backbone has been biologically proven to be safe and effective, providing strong guiding principles for the development of new drugs and compound libraries.
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| Molecular Formula |
C8H12NO7P
|
|---|---|
| Molecular Weight |
265.16
|
| Exact Mass |
265.035
|
| CAS # |
41468-25-1
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| PubChem CID |
38882
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| Appearance |
White to yellow solid powder
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| Boiling Point |
565.7ºC at 760 mmHg
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| Melting Point |
140-143 °C(lit.)
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| Flash Point |
296ºC
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| LogP |
0.453
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
17
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| Complexity |
292
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
CEEQUQSGVRRXQI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
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| Chemical Name |
(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;hydrate
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| Synonyms |
Pyridoxal 5'phosphate monohydrate; Pyridoxal 5' phosphate monohydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~5.56 mg/mL (~20.97 mM)
DMSO : ~5 mg/mL (~18.86 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (1.89 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (1.89 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7713 mL | 18.8565 mL | 37.7131 mL | |
| 5 mM | 0.7543 mL | 3.7713 mL | 7.5426 mL | |
| 10 mM | 0.3771 mL | 1.8857 mL | 3.7713 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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