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    PTACH (NCH-51)
    PTACH (NCH-51)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4578
    CAS #: 848354-66-5Purity ≥98%

    Description: PTACH (also known as NCH-51), a SAHA analog, is a novel and potent inhibitor of human histone deacetylase (HDAC). PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. NCH-51, PTACH, is a histone deacetylase (HDAC) inhibitor. NCH-51 could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. NCH-51 upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA.

    References: J Med Chem. 2005 Feb 24;48(4):1019-1032.


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    PTACH (NCH-51)

    Name: PTACH (NCH-51)
    CAS#: 848354-66-5
    Chemical Formula: C20H26N2O2S2
    Exact Mass: 390.1436
    Molecular Weight: 390.56
    Elemental Analysis: C, 61.51; H, 6.71; N, 7.17; O, 8.19; S, 16.42
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: NCH-51; NCH 51; NCH51. PTACH
    IUPAC/Chemical Name: S-(7-oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate
    InChi Key: MDYDGUOQFUQOGE-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
    SMILES Code: CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O


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