Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
In human nasal epithelial cells, prunentin suppresses the TLR4/MyD88 pathway, which in turn prevents the generation of LPS-induced inflammatory cytokines as well as the development and secretion of MUC5 AC [1].
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ADME/Pharmacokinetics |
Metabolism / Metabolites
Prunetin has known human metabolites that include 3,4,5-trihydroxy-6-[3-(4-hydroxyphenyl)-7-methoxy-4-oxochromen-5-yl]oxyoxane-2-carboxylic acid. |
References |
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Additional Infomation |
Prunetin is a hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group. It has a role as a metabolite, an EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor, an anti-inflammatory agent and an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor. It is a hydroxyisoflavone and a member of 7-methoxyisoflavones. It is functionally related to a genistein. It is a conjugate acid of a prunetin-5-olate.
Prunetin has been reported in Iris milesii, Ficus nervosa, and other organisms with data available. |
Molecular Formula |
C16H12O5
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Molecular Weight |
284.2635
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Exact Mass |
284.068
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Elemental Analysis |
C, 69.23; H, 3.10; O, 27.67
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CAS # |
552-59-0
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PubChem CID |
5281804
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Appearance |
White to off-white solid
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Density |
1.4±0.1 g/cm3
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Boiling Point |
546.5±50.0 °C at 760 mmHg
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Melting Point |
240-242ºC
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Flash Point |
209.7±23.6 °C
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Vapour Pressure |
0.0±1.5 mmHg at 25°C
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Index of Refraction |
1.669
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LogP |
3.53
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Hydrogen Bond Donor Count |
2
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Hydrogen Bond Acceptor Count |
5
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Rotatable Bond Count |
2
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Heavy Atom Count |
21
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Complexity |
424
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Defined Atom Stereocenter Count |
0
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SMILES |
O1C([H])=C(C2C([H])=C([H])C(=C([H])C=2[H])O[H])C(C2=C(C([H])=C(C([H])=C12)OC([H])([H])[H])O[H])=O
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InChi Key |
KQMVAGISDHMXJJ-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C16H12O5/c1-20-11-6-13(18)15-14(7-11)21-8-12(16(15)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
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Chemical Name |
5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one
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Synonyms |
NSC624609; HSDB 8107; NSC-624609; Pseudohypericin
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~351.79 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.79 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5179 mL | 17.5895 mL | 35.1791 mL | |
5 mM | 0.7036 mL | 3.5179 mL | 7.0358 mL | |
10 mM | 0.3518 mL | 1.7590 mL | 3.5179 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.