| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| 25g |
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Purity: ≥98%
Propranolol HCl (formerly ICI-45520, NCS-91523; AY-64043; Inderal among others), the hydrochloride salt of Propranolol, is a competitive and non-selective inhibitor of beta-adrenergic receptors with antihypertensive effects. It blocks beta-adrenergic receptors with an IC50 of 12 nM. Propranolol, a beta blocker, is used to treat a variety of conditions, including tremors, elevated blood pressure, and irregular heartbeats.
| Targets |
β adrenergic receptor ( IC50 = 12 nM )
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| Cell Assay |
In vitro, the neonatal mice cardiomyocytes (NMCMs) are treated with different drugs of different concentration, including isoproterenol (0, 1, 2.5, 5, 10, 20, and 50 μM); amiodarone (0, 1, 2.5, 5, 10, 20, and 50 μM); metoprolol (0, 10, 20, 30, 50, 100, 150, and 200 μM); propranolol (0, 10, 20, 40, 50, and 100 μM); lidocaine (0, 1, 2.5, 5, 10, 20, and 50 μM); verapamil(0, 1, 2.5, 5, 10, 20, and 50 μM);ivabradine (0, 1, 2, 3, 5, 10, and 20 μM). And the concentrations of drugs that promote CMs proliferation most significantly are chosen for subsequent experiments, including isoproterenol (10 μM), amiodarone (5 μM), metoprolol (20 μM), propranolol (20 μM), lidocaine (5 μM), verapamil (2.5 μM), ivabradine (3 μM) for NMCMs, NMCFs, and hPSC-CM.
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| Animal Protocol |
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| References |
| Molecular Formula |
C16H22CLNO2
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| Molecular Weight |
295.8
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| Exact Mass |
295.13
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| Elemental Analysis |
C, 64.97; H, 7.50; Cl, 11.98; N, 4.74; O, 10.82
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| CAS # |
318-98-9
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| Related CAS # |
(S)-(-)-Propranolol hydrochloride; 4199-10-4; Propranolol; 525-66-6; Propranolol-d7 hydrochloride; 1613439-56-7; Propranolol-d7 (ring-d7); 344298-99-3
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| Appearance |
Solid powder
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| SMILES |
CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl
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| InChi Key |
ZMRUPTIKESYGQW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
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| Chemical Name |
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (84.52 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
Solubility in Formulation 2: 5%DMSO + Corn oil: 3.0mg/ml (10.14mM) (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3807 mL | 16.9033 mL | 33.8066 mL | |
| 5 mM | 0.6761 mL | 3.3807 mL | 6.7613 mL | |
| 10 mM | 0.3381 mL | 1.6903 mL | 3.3807 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT00356603 | Active Recruiting |
Drug: Propranolol | Aggression Self-Injurious Behavior Challenging Behavior |
Rutgers, The State University of New Jersey |
January 1, 2021 | Phase 2 |
| NCT01988883 | Active Recruiting |
Drug: Placebo Drug: Modafinil Drug: Propranolol |
Postural Tachycardia Syndrome | Vanderbilt University Medical Center |
October 2014 | Early Phase 1 |
| NCT03079921 | Active Recruiting |
Drug: Phentolamine Drug: Propranolol Drug: Placebo |
Type1diabetes Hypoglycemia Islet Cell Transplantation |
University of Pennsylvania | January 20, 2017 | Early Phase 1 |
| NCT01299753 | Active Recruiting |
Drug: placebo Drug: propranolol |
Burns | Sunnybrook Health Sciences Centre |
February 2011 | Not Applicable |
| NCT06158230 | Active Recruiting |
Drug: Amitriptyline-propranolol Drug: Pizotifen |
Migraine | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh |
March 19, 2023 | Phase 2 |
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