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    Proparacaine HCl
    Proparacaine HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1653
    CAS #: 5875-06-9 Purity ≥98%

    Description: Proparacaine HCl (Proxymetacaine; Proxymetacaine), the hydrochloride salt of proparacaine, is a voltage-gated sodium channels antagonist approved as an ophthalmic solution for topical anesthetic use in ophthalmic practice. It inhibits voltage-gated sodium channels with ED50 of 3.4 mM. Proparacaine is more potent and less toxic than cocaine. Proparacaine significantly increases in FHV-1, C. felis, and 28S rDNA Ct values when fusidic acid is used. Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. 

    References: Exp Eye Res. 1994 Apr;58(4):469-78; Neurosci Lett. 2009 May 1;454(3):249-53.

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    Molecular Weight (MW)330.85 
    FormulaC16H26N2O3.HCl 
    CAS No.5875-06-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 12 mg/mL (36.3 mM) 
    Water: 66 mg/mL (199.5 mM)
    Ethanol: <1 mg/mL 
    Solubility (In vivo)Saline: 30 mg/mL  
    SynonymsProxymetacaine; Proxymetacaine


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    In Vitro

    In vitro activity: Proparacaine is more potent and less toxic than cocaine. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used.


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    In VivoProparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. 
    Animal modelMale Sprague–Dawley rats 
    Formulation & DosageDissolved in saline; 10 μmol/kg; Intrathecally 
    References

    Exp Eye Res. 1994 Apr;58(4):469-78; Neurosci Lett. 2009 May 1;454(3):249-53. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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