| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| References | |
|---|---|
| Additional Infomation |
3,3-Diphenyl-N-(1-phenylethyl)-1-propane is a diarylmethane. Fendilin is a coronary vasodilator that works by inhibiting calcium function in muscle cells during excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal drug. Fendilin is non-selective. Coronary vasodilator; inhibits calcium function in muscle cells during excitation-contraction coupling; proposed as an antiarrhythmic and antianginal drug.
|
| Molecular Formula |
C23H25N
|
|---|---|
| Molecular Weight |
315.45
|
| Exact Mass |
315.199
|
| CAS # |
13042-18-7
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| Related CAS # |
Fendiline hydrochloride; 13636-18-5
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| PubChem CID |
3336
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| Appearance |
Colorless to light yellow liquid
|
| Density |
1.031g/cm3
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| Boiling Point |
452.1ºC at 760mmHg
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| Melting Point |
200-201
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| Flash Point |
207.9ºC
|
| Vapour Pressure |
2.3E-08mmHg at 25°C
|
| Index of Refraction |
1.582
|
| LogP |
5.95
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
7
|
| Heavy Atom Count |
24
|
| Complexity |
303
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
|
| InChi Key |
NMKSAYKQLCHXDK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3
|
| Chemical Name |
3,3-diphenyl-N-(1-phenylethyl)propan-1-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Typically soluble in DMSO (e.g. 10 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1701 mL | 15.8504 mL | 31.7007 mL | |
| 5 mM | 0.6340 mL | 3.1701 mL | 6.3401 mL | |
| 10 mM | 0.3170 mL | 1.5850 mL | 3.1701 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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