| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Human Endogenous Metabolite
α-D-Glucose-1-phosphate disodium hydrate does not have a specific biological target itself but is a key metabolite in carbohydrate metabolism. It is a substrate for the enzyme phosphoglucomutase, which converts it to glucose-6-phosphate, a central molecule in glycolysis and gluconeogenesis. It is also a substrate for UDP-glucose pyrophosphorylase, which produces UDP-glucose for glycogen synthesis. Its role as a metabolic intermediate makes it important for studying energy metabolism and glycogen storage diseases. |
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| ln Vitro |
In vitro studies of α-D-Glucose-1-phosphate disodium hydrate typically involve its use as a substrate in enzymatic assays to study carbohydrate metabolism. It is used to investigate the activity of enzymes such as phosphoglucomutase, UDP-glucose pyrophosphorylase, and glycogen phosphorylase. The compound is also used as a starting material for the synthesis of glucuronic acid and in studies of glycogen metabolism. It may be used in cell culture to study glucose metabolism and energy homeostasis.
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| ln Vivo |
In vivo, α-D-Glucose-1-phosphate disodium hydrate is a crucial intermediate in glycogen metabolism. It is formed from glycogen by the action of glycogen phosphorylase and is converted to glucose-6-phosphate by phosphoglucomutase. The compound is used in research to study metabolic disorders such as glycogen storage diseases and diabetes. It is also used in circulatory system research and as a potential therapeutic agent for heart disease.
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| Enzyme Assay |
In vitro enzyme assays for α-D-Glucose-1-phosphate disodium hydrate typically involve studying its interaction with enzymes of carbohydrate metabolism. Enzyme activity assays can be performed to measure the conversion of glucose-1-phosphate to glucose-6-phosphate by phosphoglucomutase or to UDP-glucose by UDP-glucose pyrophosphorylase. The compound may also be used in assays to study the activity of glycogen phosphorylase, which produces glucose-1-phosphate from glycogen.
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| Cell Assay |
α-D-Glucose-1-phosphate disodium hydrate is used in cell-based assays to study carbohydrate metabolism and energy homeostasis. Cells may be treated with the compound to study its effects on glucose metabolism or to investigate the activity of enzymes involved in glycogen synthesis and breakdown. It may also be used in studies of insulin signaling and glucose uptake. The compound is also used as a cell culture supplement in some applications.
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| Animal Protocol |
In vivo animal studies using α-D-Glucose-1-phosphate disodium hydrate are typically conducted in the context of studying carbohydrate metabolism and metabolic disorders. Animal models of diabetes, glycogen storage diseases, or heart disease may be used to study the effects of the compound on glucose metabolism and energy homeostasis. The compound may be administered to animals to study its pharmacokinetics and effects on metabolic parameters.
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| ADME/Pharmacokinetics |
α-D-Glucose-1-phosphate disodium hydrate has a molecular formula of C6H11Na2O9P (anhydrous) and a molecular weight of 304.10 (anhydrous). The compound is typically supplied as a hydrate. It is an important intermediate in carbohydrate metabolism and is used in various biochemical and pharmaceutical research applications. It should be stored according to the manufacturer's recommendations.
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| Toxicity/Toxicokinetics |
The toxicity profile of α-D-Glucose-1-phosphate disodium hydrate as a standalone compound is not extensively characterized, as it is a natural metabolite. It is generally considered safe for use in biochemical research. The compound is intended for research use only and is not approved for therapeutic use in humans. Standard laboratory safety practices should be followed when handling this compound.
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| References | |
| Additional Infomation |
α-D-Glucose-1-phosphate disodium hydrate (CAS 230954-92-4) is a phosphorylated sugar derivative of glucose. It is an important intermediate in carbohydrate metabolism, particularly in the pathways of glycogenolysis and glycogenesis. The compound is used as a starting material for the synthesis of glucuronic acid. It could be utilized as a cell inhibitor, antibiotic, immunosuppressant, and circulatory system research material necessary for heart disease study.
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| Molecular Formula |
C6H11O9P-2.2[NA+].H2O
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|---|---|
| Molecular Weight |
322.11482
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| Exact Mass |
322.004
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| CAS # |
230954-92-4
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| Related CAS # |
α-D-Glucose-1-phosphate disodium;56401-20-8
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| PubChem CID |
16219389
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
19
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| Complexity |
266
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| Defined Atom Stereocenter Count |
5
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| SMILES |
C(C1C(C(C(C(O1)OP(=O)([O-])[O-])O)O)O)O.O.[Na+].[Na+]
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| InChi Key |
YWAUQXHOCBBYLP-FBNUBEQJSA-L
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| InChi Code |
InChI=1S/C6H13O9P.2Na.H2O/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5-,6-;;;/m1.../s1
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| Chemical Name |
disodium;[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate;hydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O :~250 mg/mL (~776.13 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (103.47 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1045 mL | 15.5226 mL | 31.0453 mL | |
| 5 mM | 0.6209 mL | 3.1045 mL | 6.2091 mL | |
| 10 mM | 0.3105 mL | 1.5523 mL | 3.1045 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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