| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
|
||
| 100mg | |||
| Other Sizes |
| Targets |
Isobutyryl-L-carnitine chloride does not have a single specific biological target but is involved in fatty acid oxidation and organic acid metabolism. It is a product of the acyl-CoA dehydrogenases. As an acylcarnitine, it is involved in the transport of fatty acids into the mitochondria for β-oxidation. Elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency, a metabolic disorder.
|
|---|---|
| ln Vitro |
In vitro studies of isobutyryl-L-carnitine chloride typically involve its use as a reference standard in metabolomics research. It is used to study fatty acid oxidation and organic acid metabolism. The compound may be used in enzymatic assays to study the activity of acyl-CoA dehydrogenases and other enzymes involved in fatty acid metabolism. It is also used as a biomarker for metabolic disorders.
|
| ln Vivo |
In vivo, isobutyryl-L-carnitine chloride is involved in fatty acid oxidation and organic acid metabolism. Elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency. The compound is a product of the acyl-CoA dehydrogenases. It plays a role in the transport of fatty acids into the mitochondria for energy production. Its levels in blood and urine can be used as a biomarker for metabolic disorders.
|
| Enzyme Assay |
In vitro enzyme assays for isobutyryl-L-carnitine chloride typically involve studying its metabolism by enzymes such as acyl-CoA dehydrogenases. Enzyme activity assays can be performed to measure the conversion of isobutyryl-CoA to other metabolites. The compound may also be used in assays to study the activity of carnitine acyltransferases and other enzymes involved in fatty acid metabolism.
|
| Cell Assay |
In vitro cell-based assays using isobutyryl-L-carnitine chloride may involve the treatment of cultured cells with the compound to study fatty acid oxidation. Cells may be treated with the compound, and its effects on fatty acid metabolism and energy production are measured. The compound may also be used in studies of metabolic disorders such as isobutyryl-CoA dehydrogenase deficiency.
|
| ADME/Pharmacokinetics |
Isobutyryl-L-carnitine chloride has a molecular formula of C11H22ClNO4 and a molecular weight of 267.75. The CAS number is 6920-31-6. The compound is a natural 4-carbon acylcarnitine involved in fatty acid oxidation. It is a product of the acyl-CoA dehydrogenases. The compound is intended for research use only.
|
| Toxicity/Toxicokinetics |
The toxicity profile of isobutyryl-L-carnitine chloride is not extensively characterized, as it is a naturally occurring metabolite. Elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency. The compound is intended for research use only and is not approved for therapeutic use in humans. Standard laboratory safety practices should be followed when handling this compound.
|
| References | |
| Additional Infomation |
Isobutyryl-L-carnitine chloride (CAS 6920-31-6) is a natural 4-carbon acylcarnitine that is involved in fatty acid oxidation and organic acid metabolism. It is a derivative of L-carnitine and a product of the acyl-CoA dehydrogenases. Elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency. It has a molecular formula of C11H22ClNO4.
|
| Molecular Formula |
C11H22CLNO4
|
|---|---|
| Molecular Weight |
267.75
|
| Exact Mass |
267.124
|
| CAS # |
6920-31-6
|
| Related CAS # |
Isobutyryl-L-carnitine;25518-49-4;Isobutyryl-L-carnitine-d3 chloride
|
| PubChem CID |
71749537
|
| Appearance |
White to off-white solid powder
|
| LogP |
0.202
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
17
|
| Complexity |
255
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
CC(C)C(=O)O[C@H](CC(=O)O)C[N+](C)(C)C.[Cl-]
|
| InChi Key |
FWUACOYFRJEMMP-SBSPUUFOSA-N
|
| InChi Code |
InChI=1S/C11H21NO4.ClH/c1-8(2)11(15)16-9(6-10(13)14)7-12(3,4)5;/h8-9H,6-7H2,1-5H3;1H/t9-;/m1./s1
|
| Chemical Name |
[(2R)-3-carboxy-2-(2-methylpropanoyloxy)propyl]-trimethylazanium;chloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O :~250 mg/mL (~933.71 mM)
DMSO :~30 mg/mL (~112.04 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (373.48 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7348 mL | 18.6741 mL | 37.3483 mL | |
| 5 mM | 0.7470 mL | 3.7348 mL | 7.4697 mL | |
| 10 mM | 0.3735 mL | 1.8674 mL | 3.7348 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
