Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Targets |
WNT5A[1]
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ln Vivo |
In an orthotopic mouse model, Foxy-5 efficiently inhibits the metastatic spread of WNT5A-low prostate cancer cells[1]. In a xenograft mouse model of human colon cancer, Foxy-5 decreases the quantity of colonic cancer stem cells[2].
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References |
[1]. Säfholm A, et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.
[2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728. [3]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. [4]. Kelsey R. Prostate cancer: Foxy-5 in prostate cancer model. Nat Rev Urol. 2017 Nov;14(11):638. |
Molecular Formula |
C28H43F3N6O14S2
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Molecular Weight |
808.80
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Related CAS # |
Foxy-5;881188-51-8
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Solubility (In Vitro) |
H2O :~20 mg/mL (~24.73 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 7.14 mg/mL (8.83 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.2364 mL | 6.1820 mL | 12.3640 mL | |
5 mM | 0.2473 mL | 1.2364 mL | 2.4728 mL | |
10 mM | 0.1236 mL | 0.6182 mL | 1.2364 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.