| Size | Price | Stock | Qty |
|---|---|---|---|
| 10g |
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| Other Sizes |
| Targets |
Palatinose hydrate targets carbohydrate metabolism and digestive enzymes. As a disaccharide, it is hydrolyzed by intestinal enzymes such as sucrase-isomaltase. Its "target" in research is the study of carbohydrate digestion, glycemic response, and metabolic effects of slowly digestible carbohydrates. It is used as a low-glycemic sweetener in food research.
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|---|---|
| ln Vitro |
In vitro, Palatinose hydrate is used to study carbohydrate digestion and enzyme kinetics. It is a substrate for sucrase-isomaltase and other glycoside hydrolases. Its activity is measured by assessing the rate of hydrolysis to glucose and fructose, which can be monitored by spectrophotometric or chromatographic methods. It is similar to sucrose in its physicochemical properties.
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| ln Vivo |
In vivo, Palatinose hydrate is a disaccharide that is digested more slowly than sucrose, resulting in a lower glycemic response. It is produced from sucrose by the action of sucrose isomerase in some bacteria. It is used in food research to study carbohydrate metabolism, glycemic control, and the effects of slowly digestible carbohydrates on metabolic health.
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| Enzyme Assay |
In vitro enzyme assays with Palatinose hydrate typically involve studying glycoside hydrolases such as sucrase-isomaltase, α-glucosidase, and invertase. The compound is used as a substrate to measure enzyme activity. Standard assays involve incubating palatinose with enzyme preparations and measuring the release of glucose and fructose by spectrophotometric or chromatographic methods.
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| Cell Assay |
In vitro cell culture experiments with Palatinose hydrate are not typically performed as the compound is a disaccharide that acts on digestive enzymes rather than directly on mammalian cells. However, it may be used in co-culture systems with intestinal epithelial cells to study carbohydrate digestion and absorption. Endpoints include assessment of glucose transport and metabolic effects.
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| Animal Protocol |
In vivo animal experiments with Palatinose hydrate typically involve administering the compound via oral gavage or dietary incorporation to study its effects on glycemic response, insulin levels, and metabolic health. Key endpoints include blood glucose measurements, insulin levels, and metabolic parameters. These studies evaluate the effects of slowly digestible carbohydrates on metabolism.
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| ADME/Pharmacokinetics |
The pharmacokinetic (PK) properties of Palatinose hydrate reflect its role as a slowly digestible disaccharide. It is hydrolyzed in the small intestine by sucrase-isomaltase to glucose and fructose, which are absorbed. Its glycemic response is lower than that of sucrose. It has a melting point of 118.0-127.0°C and appears as a white to almost white powder.
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| Toxicity/Toxicokinetics |
Palatinose hydrate has a low toxicity profile as a naturally occurring disaccharide. It is generally recognized as safe for consumption as a food ingredient. For research use, standard laboratory safety practices are sufficient. It is not classified as a hazardous substance. It should be stored in a sealed, protected environment away from moisture.
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| Additional Infomation |
Palatinose hydrate (Isomaltulose hydrate) is a disaccharide with an α(1→6) linkage between D-glucose and D-fructose. It is produced from sucrose by sucrose isomerase in some bacteria and is similar to sucrose in physicochemical properties. It is used in food research as a low-glycemic sweetener. The compound is not a drug and has no therapeutic indications.
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| CAS # |
343336-76-5
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|---|---|
| Related CAS # |
D-Melibiose;585-99-9
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| Appearance |
White to off-white solid powder
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| Density |
1.77g/cm3
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| Boiling Point |
684.1ºC at 760 mmHg
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| Melting Point |
123 °C
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| Flash Point |
367.5ºC
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| Index of Refraction |
1.656
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| LogP |
0
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 125 mg/mL
H2O: 100 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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