| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
| Targets |
Devaleryl Valsartan Impurity is an impurity of valsartan, which is an angiotensin II type 1 (AT1) receptor antagonist. Valsartan is used in the initial treatment for high blood pressure as are ACE inhibitors. The impurity does not have a defined pharmacological target.
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|---|---|
| ln Vitro |
Devaleryl Valsartan Impurity does not exhibit significant pharmacological activity. It is a chemical impurity and degradation product of valsartan. Its primary use is as a reference standard for the identification and quantification of impurities in valsartan formulations by HPLC.
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| ln Vivo |
In vivo, Devaleryl Valsartan Impurity is not administered as a therapeutic agent. It may be present as a trace impurity in valsartan formulations. Its safety and toxicological profile are assessed in the context of pharmaceutical quality control to ensure that impurity levels remain below acceptable limits.
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| Enzyme Assay |
In vitro assays for Devaleryl Valsartan Impurity typically involve its use as a reference standard in HPLC or LC-MS methods for impurity profiling of valsartan. The compound is characterized by its retention time, UV spectrum, and mass spectrum. System suitability tests are performed to ensure proper separation from valsartan and other impurities.
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| Cell Assay |
For in vitro cell assays, Devaleryl Valsartan Impurity is not typically used as a treatment. It may be tested for cytotoxicity in cell-based assays to assess its safety as an impurity. Cells are cultured and treated with the compound at various concentrations, and cell viability is assessed by standard assays. Results are used to establish acceptable impurity limits.
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| Animal Protocol |
For in vivo animal studies, Devaleryl Valsartan Impurity is not typically administered as a therapeutic agent. Toxicological studies may be conducted to assess the safety of this impurity at relevant exposure levels. Animals are administered valsartan formulations containing the impurity, and toxicological endpoints are monitored.
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| ADME/Pharmacokinetics |
Devaleryl Valsartan Impurity (MW 351.4) has the molecular formula C₁₉H₂₁N₅O₂. The compound is stable as a powder at -20°C for up to 3 years and in solvent at -80°C for up to 1 year. It is a degradation product of valsartan formed under acidic conditions.
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| Toxicity/Toxicokinetics |
The compound is for research use only. No specific toxicity data are available. As a pharmaceutical impurity, its toxicity is assessed in the context of quality control to ensure patient safety. Standard laboratory safety precautions should be followed when handling this compound.
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| References |
[1]. A Sampath, et al. Identification and characterization of potential impurities of valsartan, AT1 receptor antagonist. J Pharm Biomed Anal. 2009 Oct 15;50(3):405-12.
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| Additional Infomation |
Devaleryl Valsartan Impurity (CAS# 676129-92-3) is a designated impurity of the angiotensin II receptor blocker valsartan. It has not been approved as a therapeutic agent. The compound is used as a reference standard in pharmaceutical quality control for impurity profiling of valsartan formulations. It is also known as Valsartan Impurity B.
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| Molecular Formula |
C19H21N5O2
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|---|---|
| Molecular Weight |
351.40
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| Exact Mass |
351.169
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| CAS # |
676129-92-3
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| PubChem CID |
10315945
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
598.2±60.0 °C at 760 mmHg
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| Flash Point |
315.6±32.9 °C
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| Vapour Pressure |
0.0±1.8 mmHg at 25°C
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| Index of Refraction |
1.609
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| LogP |
3.52
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
26
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| Complexity |
453
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC(C)[C@H](NCC1=CC=C(C2=C(C3N=NNN=3)C=CC=C2)C=C1)C(O)=O
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| InChi Key |
NSXSCTCKWRSTHJ-KRWDZBQOSA-N
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| InChi Code |
InChI=1S/C19H21N5O2/c1-12(2)17(19(25)26)20-11-13-7-9-14(10-8-13)15-5-3-4-6-16(15)18-21-23-24-22-18/h3-10,12,17,20H,11H2,1-2H3,(H,25,26)(H,21,22,23,24)/t17-/m0/s1
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| Chemical Name |
(2S)-3-methyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methylamino]butanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 250 mg/mL (711.44 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8458 mL | 14.2288 mL | 28.4576 mL | |
| 5 mM | 0.5692 mL | 2.8458 mL | 5.6915 mL | |
| 10 mM | 0.2846 mL | 1.4229 mL | 2.8458 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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