| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
| Targets |
Homovanillyl alcohol does not have a specific pharmacological target but is studied as a metabolite and biomarker. It is a downstream metabolite of dopamine and a potential therapeutic target for prostate cancer cells. Its presence and concentration in biological fluids can reflect the metabolic status of dopamine and the impact of dietary polyphenols.
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|---|---|
| ln Vitro |
In vitro, homovanillyl alcohol is a reactive oxidative byproduct of dopamine. It has been shown to be a potential therapeutic target for prostate cancer cells. It can be used as a model system to study the metabolism of phenolic compounds and their biological effects. Its antioxidant properties are also of interest in research.
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| ln Vivo |
In vivo, homovanillyl alcohol is involved in various metabolic pathways. As a metabolite of dopamine, it plays a role in the metabolism of neurotransmitters. As a component of virgin olive oil and wine, it is consumed in the diet and may contribute to the health benefits associated with the Mediterranean diet.
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| Enzyme Assay |
In vitro assays for homovanillyl alcohol typically involve its detection and quantification in biological samples such as plasma, urine, and tissue extracts. The compound is analyzed by HPLC or LC-MS. Its antioxidant activity is assessed using DPPH, ABTS, or FRAP assays. Its effects on cancer cell lines are evaluated by MTT or proliferation assays.
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| Cell Assay |
For in vitro cell assays, prostate cancer cells or other cell lines are cultured and treated with homovanillyl alcohol. Cell viability and proliferation are assessed by MTT or SRB assays. The compound's effects on signaling pathways are evaluated by Western blot. Its antioxidant effects are measured by assessing ROS levels.
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| Animal Protocol |
For in vivo animal studies, homovanillyl alcohol is typically studied as a biomarker. Animals are administered dopamine precursors or dietary polyphenols, and the compound is measured in plasma and urine by LC-MS. Its levels are correlated with neurological or metabolic conditions.
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| ADME/Pharmacokinetics |
Homovanillyl alcohol (MW 168.19) has the molecular formula C₉H₁₂O₃. It is also known as 4-(2-hydroxyethyl)-2-methoxyphenol. The compound is typically a solid and is soluble in water and organic solvents. It is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
The compound is for research use only. No specific toxicity data are available. As an endogenous metabolite and dietary component, it is expected to have low toxicity at physiological concentrations. Standard laboratory safety precautions should be followed.
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| References |
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| Additional Infomation |
(4-Hydroxy-3-methoxyphenyl)ethanol belongs to the methoxybenzene and phenolic compounds. Homovanillol has been reported to exist in Metasequoia glyptostroboides, Chrysanthemum mesenteroides, and other organisms with relevant data. Homovanillol is a metabolite of Saccharomyces cerevisiae, present in or produced by the yeast. It is a metabolite of serotonin and norepinephrine.
Homovanillyl alcohol (CAS# 2380-78-1) is a metabolite of dopamine and a phenolic compound found in olive oil and wine. It has not been approved as a therapeutic drug. The compound is used in research on dopamine metabolism, neurodegenerative diseases, and as a biomarker for dietary polyphenol intake. It is also known as 4-hydroxy-3-methoxyphenylethanol. |
| Molecular Formula |
C9H12O3
|
|---|---|
| Molecular Weight |
168.19
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| Exact Mass |
168.078
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| CAS # |
2380-78-1
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| PubChem CID |
16928
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
316.8±27.0 °C at 760 mmHg
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| Melting Point |
40 - 42 °C
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| Flash Point |
145.4±23.7 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.559
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| LogP |
0.33
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
12
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| Complexity |
127
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=C(C=CC(=C1)CCO)O
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| InChi Key |
XHUBSJRBOQIZNI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H12O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,10-11H,4-5H2,1H3
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| Chemical Name |
4-(2-hydroxyethyl)-2-methoxyphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ≥ 100 mg/mL (594.57 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.86 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.9457 mL | 29.7283 mL | 59.4566 mL | |
| 5 mM | 1.1891 mL | 5.9457 mL | 11.8913 mL | |
| 10 mM | 0.5946 mL | 2.9728 mL | 5.9457 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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