Size | Price | Stock | Qty |
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5g |
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Other Sizes |
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Targets |
GABA Receptor[1]
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ln Vitro |
Applying nipecotic acid (1 mM) to outside-out patches of paraventricular neurones induced inward unitary currents[1].
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ln Vivo |
The blood-brain barrier (BBB) is not easily crossed by nipecotic acid[2].
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References |
[1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8.
[2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. |
Molecular Formula |
C6H11NO2
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Molecular Weight |
129.16
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CAS # |
498-95-3
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SMILES |
O([H])C(C1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O: 50 mg/mL (387.12 mM)
DMSO: < 1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (387.12 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 7.7423 mL | 38.7117 mL | 77.4234 mL | |
5 mM | 1.5485 mL | 7.7423 mL | 15.4847 mL | |
10 mM | 0.7742 mL | 3.8712 mL | 7.7423 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.