Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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50mg |
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Other Sizes |
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Targets |
cannabinoid type-2 receptors
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ln Vitro |
The capacity of CP55940 and 2-AG, but not AEA, to activate [35S]GTPγS binding to CB2Rs is greatly increased by CB2R PAM (100 nM)[1].
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ln Vivo |
CB2R PAM exhibits antinociceptive action at doses of 1–20 mg/kg; po[1].
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Animal Protocol |
Animal/Disease Models: Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)[1]
Doses: 1, 5, 10, 20 mg/ kg Route of Administration: Po Experimental Results: Dramatically increased licking latency in the animals starting from 5 mg/kg. |
References |
[1]. Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287.
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Molecular Formula |
C21H24BRFN2O2
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Molecular Weight |
435.33
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CAS # |
2244579-87-9
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SMILES |
BrC1=CN(CC2C=CC(=CC=2)F)C(C(=C1C)NC(C1CCCCCC1)=O)=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 50 mg/mL (114.86 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (5.74 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2971 mL | 11.4855 mL | 22.9711 mL | |
5 mM | 0.4594 mL | 2.2971 mL | 4.5942 mL | |
10 mM | 0.2297 mL | 1.1486 mL | 2.2971 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.