| Size | Price | Stock | Qty |
|---|---|---|---|
| 2mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
DL-Tartaric acid-d2 does not have a biological target as it is an analytical standard. Its non-deuterated form, tartaric acid, is a naturally occurring organic acid that is used as a chiral agent and stabilizer in chemical and biochemical reactions. Tartaric acid is not a pharmacologically active compound. The labeled compound is used as an internal standard for the quantification of tartaric acid in biological and food samples.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as tracers that influence measurement during the drug development process. It's possible that the pharmacokinetics and functional range of medications contribute to the concern over mutagenesis [1].
The labeled compound does not possess in vitro biological activity. Tartaric acid is an organic acid that is not pharmacologically active. The labeled compound is used as an analytical standard for the quantification of tartaric acid, not for evaluating its own biological activity. |
| ln Vivo |
DL-Tartaric acid-d2 does not have in vivo biological activity and is not used for therapeutic purposes. Tartaric acid is a naturally occurring organic acid found in fruits. The labeled compound is used as an internal standard for the quantification of tartaric acid in biological and food samples.
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| Enzyme Assay |
In vitro assays for DL-tartaric acid-d2 focus on its use as an analytical standard. A standard protocol involves preparing a solution of the compound in an appropriate solvent (e.g., water) and using it as an internal standard for LC-MS or GC-MS analysis of tartaric acid in food products, beverages, or biological samples. The compound is added to samples before extraction and analysis. Quantification is performed by monitoring specific mass transitions.
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| Cell Assay |
Cell-based experiments are not performed with DL-tartaric acid-d2, as it is an analytical standard. The compound is used exclusively in analytical chemistry applications.
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| Animal Protocol |
In vivo animal studies are not conducted with DL-tartaric acid-d2. When used in metabolic studies, the labeled compound serves as an internal standard for the quantification of tartaric acid in animal tissues or biological fluids.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of DL-tartaric acid-d2 are not characterized, as it is not a drug substance. Tartaric acid is metabolized and excreted. The labeled compound is used as an internal standard for metabolic studies.
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| Toxicity/Toxicokinetics |
DL-Tartaric acid-d2 is not a therapeutic agent and has not been evaluated for toxicity in humans. Tartaric acid is generally recognized as safe as a food additive. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves and safety glasses.
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| References | |
| Additional Infomation |
DL-Tartaric acid-d2 is a stable isotope-labeled internal standard used for the quantification of tartaric acid in food, beverage, and biological samples. It is also known as (±)-tartaric-2,3-d2 acid. The compound is used in analytical method development, quality control, and food safety testing.
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| Molecular Formula |
C4H6O6
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|---|---|
| Molecular Weight |
150.09
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| Exact Mass |
152.028
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| CAS # |
181376-62-5
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| Related CAS # |
DL-Tartaric acid;133-37-9
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| PubChem CID |
12222903
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| Appearance |
White to light yellow solid powder
|
| LogP |
-1.9
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
10
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| Complexity |
134
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| Defined Atom Stereocenter Count |
2
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| SMILES |
[C@@]([H])(O)(C(=O)O)[C@]([H])(O)C(=O)O
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| InChi Key |
FEWJPZIEWOKRBE-DSWNTLALSA-N
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| InChi Code |
InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m0/s1/i1D,2D
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| Chemical Name |
(2S,3S)-2,3-dideuterio-2,3-dihydroxybutanedioic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~657.5 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.44 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.44 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (16.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6627 mL | 33.3133 mL | 66.6267 mL | |
| 5 mM | 1.3325 mL | 6.6627 mL | 13.3253 mL | |
| 10 mM | 0.6663 mL | 3.3313 mL | 6.6627 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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