| Size | Price | Stock | Qty |
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| 1mg |
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| Other Sizes |
| Targets |
11-Methoxyyangonin targets pathways involved in anxiolytic activity as a kavalactone. Kavalactones are known to interact with various neurotransmitter systems including GABAergic, glutamatergic, and monoaminergic pathways. As a bioactive marker for Kava, it contributes to the pharmacological effects of Piper methysticum. The compound's structure as an aromatic ether belonging to the 2-pyranone class provides specific features for biological interactions. Further research is needed to identify its specific molecular targets and mechanisms of action.
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| ln Vitro |
In vitro studies of 11-Methoxyyangonin have focused on its role as a natural kavalactone and bioactive marker for Kava. The compound's chemical structure has been characterized as an aromatic ether belonging to the 2-pyranone class. Its presence in Polygala tenuifolia has been documented. The compound's purity of >98% (HPLC) supports its use in research applications. These in vitro studies provide foundational data for understanding the compound's properties and its potential applications in anxiolytic research.
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| ln Vivo |
In vivo studies of 11-Methoxyyangonin are limited as the compound is primarily used as a research chemical. As a kavalactone, it may contribute to the anxiolytic effects of Kava in vivo. Kavalactones have been studied in animal models for their anxiolytic and sedative effects. However, comprehensive in vivo studies specifically targeting 11-Methoxyyangonin are not well documented in the available literature. The compound is intended for research use only and is not for human therapeutic use.
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| Enzyme Assay |
In vitro receptor binding assays for 11-Methoxyyangonin typically involve testing its interactions with neurotransmitter receptors relevant to anxiolytic activity. Receptor binding studies may utilize cell-based assays expressing GABA receptors, glutamate receptors, or other relevant targets. The compound's purity and identity are assessed using analytical chemistry methods such as nuclear magnetic resonance spectroscopy, high-performance liquid chromatography, and mass spectrometry. All assays are performed with appropriate controls and standardized protocols to ensure reproducibility of results.
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| Cell Assay |
In vitro cell-based assays for 11-Methoxyyangonin involve culturing neuronal cells to evaluate its anxiolytic and neuroactive effects. Cells are treated with varying concentrations of the compound and neurotransmitter receptor activation is measured using calcium imaging or electrophysiological methods. Cell viability is assessed using MTT or similar colorimetric assays. For receptor binding studies, radioligand binding assays may be performed. All experiments are performed in triplicate with appropriate controls to ensure statistical reliability.
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| Animal Protocol |
In vivo animal experiments for 11-Methoxyyangonin would be conducted to evaluate its anxiolytic activity. Animal models of anxiety such as elevated plus maze, open field test, or light-dark box test would be used. Animals would be administered the compound and behavioral parameters assessed. For toxicology studies, animals would be administered the compound and observed for signs of toxicity. Parameters assessed would include body weight, organ weights, and histopathology. Control groups receiving vehicle alone would be included for comparison. All procedures would comply with institutional animal care and use committee guidelines.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 11-Methoxyyangonin reflect its nature as a small kavalactone. It has a molecular weight of 288.30 and the molecular formula C16H16O5. The compound is soluble in DMSO at 16.67 mg/mL (57.82 mM). As a lipophilic kavalactone, it can cross the blood-brain barrier, which is relevant for its potential anxiolytic effects. The compound is expected to be metabolized through standard xenobiotic pathways in the liver. Complete pharmacokinetic profiling including half-life, clearance, volume of distribution, and bioavailability would require further systematic studies.
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| Toxicity/Toxicokinetics |
The toxicity profile of 11-Methoxyyangonin has been evaluated in the context of its use as a research chemical. As a natural kavalactone, it is expected to have a safety profile similar to other kavalactones. Kava extracts have been associated with hepatotoxicity at high doses. Proper handling procedures including use of personal protective equipment are recommended when working with pure compound. The compound is not approved for human therapeutic use and is intended for research purposes only. Long-term toxicity studies would be needed to fully establish its safety profile.
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| Additional Infomation |
11-Methoxygiganin is an aromatic ether belonging to the 2-pyranone class of compounds. It has been reported that 11-methoxygiganin exists in Polygala tenuifolia, and relevant data are available for reference.
11-Methoxyyangonin (CAS# 2743-14-8) is a natural kavalactone with the molecular formula C16H16O5 and a molecular weight of 288.30. Also known as 6-(3,4-dimethoxystyryl)-4-methoxy-2H-pyran-2-one, it is utilized in the research of anxiolytic activity. It acts as a bioactive marker for Piper methysticum (Kava) and has been reported in Polygala tenuifolia. The compound is an aromatic ether belonging to the 2-pyranone class. It has a purity of >98% (HPLC) and is soluble in DMSO at 16.67 mg/mL. It is intended for research use only. |
| Molecular Formula |
C16H16O5
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|---|---|
| Molecular Weight |
288.30
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| Exact Mass |
288.1
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| CAS # |
2743-14-8
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| PubChem CID |
5458436
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.22g/cm3
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| Boiling Point |
505.8ºC at 760 mmHg
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| Flash Point |
226.4ºC
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| Vapour Pressure |
2.35E-10mmHg at 25°C
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| Index of Refraction |
1.569
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| LogP |
2.836
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
21
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| Complexity |
463
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=C(C=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC)OC
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| InChi Key |
GBJRDULCMRSYSL-GQCTYLIASA-N
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| InChi Code |
InChI=1S/C16H16O5/c1-18-13-9-12(21-16(17)10-13)6-4-11-5-7-14(19-2)15(8-11)20-3/h4-10H,1-3H3/b6-4+
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| Chemical Name |
6-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-4-methoxypyran-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 16.67 mg/mL (57.82 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (5.79 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4686 mL | 17.3430 mL | 34.6861 mL | |
| 5 mM | 0.6937 mL | 3.4686 mL | 6.9372 mL | |
| 10 mM | 0.3469 mL | 1.7343 mL | 3.4686 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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