| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Multiple targets including antioxidant pathways, inflammatory mediators, and immune cells. Sibiricose A1, as a phenylpropanoid glycoside, exhibits antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective activities. The compound may scavenge free radicals, inhibit the production of pro-inflammatory mediators, modulate immune cell function, and protect neurons from damage. Its mechanism of action may involve modulation of various signaling pathways including NF-κB, MAPK, and Nrf2.
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| ln Vitro |
Sibiricose A1 exhibits antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective activities. The compound may scavenge free radicals and reduce oxidative stress, inhibit the production of inflammatory mediators, modulate immune cell function, and protect neurons from damage. Its specific in vitro activities depend on the concentrations tested and the assay systems used. Further studies are needed to fully characterize its activity profile.
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| ln Vivo |
In vivo studies of sibiricose A1 are limited. As a phenylpropanoid glycoside from Acanthopanax senticosus, it may contribute to the pharmacological effects of Siberian ginseng, which has been used in traditional medicine for its adaptogenic, immunomodulatory, and neuroprotective properties. Further in vivo studies are needed to characterize its specific pharmacokinetic and pharmacodynamic properties.
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| Enzyme Assay |
Non-cell-based assays for sibiricose A1 include antioxidant assays such as DPPH radical scavenging, ABTS, and FRAP assays. Anti-inflammatory activity can be measured by inhibition of COX-2, LOX, or cytokine production in enzyme assays. Immunomodulatory activity can be assessed using lymphocyte proliferation assays. Standard analytical methods including HPLC, NMR, and mass spectrometry are used for compound characterization.
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| Cell Assay |
Cell-based assays for sibiricose A1 use various cell lines to assess its biological activities. Macrophage cell lines (e.g., RAW 264.7) are stimulated with LPS and treated with the compound, and inflammatory mediators in culture supernatant are measured. For immunomodulatory studies, splenocytes or peripheral blood mononuclear cells are treated with the compound and proliferation or cytokine production is measured. For neuroprotective studies, neuronal cell lines are exposed to oxidative stress inducers and treated with the compound.
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| Animal Protocol |
In vivo studies of sibiricose A1 are limited. Based on its biological activities, potential animal models include: carrageenan-induced paw edema models for anti-inflammatory evaluation; immunosuppression models for immunomodulatory evaluation; and neurodegeneration models for neuroprotective evaluation. Standard protocols for these models involve administration of the compound followed by measurement of relevant endpoints.
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| ADME/Pharmacokinetics |
Sibiricose A1 has a molecular formula of C₂₆H₃₀O₁₄ and a molecular weight of approximately 566.51 g/mol. The CAS number is 139726-40-2. It is a naturally occurring phenylpropanoid glycoside found in various plant species including Acanthopanax senticosus (Siberian ginseng). The compound should be stored under recommended conditions. It is intended for research use only.
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| Toxicity/Toxicokinetics |
Specific toxicity data for sibiricose A1 are limited. As a natural phenylpropanoid glycoside, it is generally considered to have low toxicity. Standard laboratory safety practices should be followed when handling this compound, including the use of personal protective equipment. It is intended for research use only.
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| References | |
| Additional Infomation |
Siberian sugar A1 is a hydroxycinnamic acid. It has been reported that Siberian sugar A1 exists in Polygala tenuifolia, Polygala sibirica, and Polygala sibirica, and there is relevant data available.
Sibiricose A1 is a naturally occurring phenylpropanoid glycoside found in various plant species, including Acanthopanax senticosus (Siberian ginseng) and other medicinal plants. Phenylpropanoid glycosides are a class of compounds known for their diverse biological activities including antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective effects. Acanthopanax senticosus has been used in traditional medicine as an adaptogen for its stress-protective and immune-enhancing properties. Sibiricose A1 is used as a reference standard for the identification and quantification of phenylpropanoid glycosides in plant extracts and for research purposes. It is for research use only. |
| Molecular Formula |
C23H32O15
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|---|---|
| Molecular Weight |
548.49
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| Exact Mass |
548.174
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| CAS # |
139726-40-2
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| PubChem CID |
6326016
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
-2
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| Hydrogen Bond Donor Count |
8
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| Hydrogen Bond Acceptor Count |
15
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
38
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| Complexity |
783
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| Defined Atom Stereocenter Count |
9
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| SMILES |
COC1=CC(=CC(=C1O)OC)/C=C/C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O[C@]3([C@H]([C@@H]([C@H](O3)CO)O)O)CO)O)O)O
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| InChi Key |
DJBWDHVUJCXYBH-IBVGEFGBSA-N
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| InChi Code |
InChI=1S/C23H32O15/c1-33-11-5-10(6-12(34-2)16(11)27)3-4-15(26)35-8-14-17(28)19(30)20(31)22(36-14)38-23(9-25)21(32)18(29)13(7-24)37-23/h3-6,13-14,17-22,24-25,27-32H,7-9H2,1-2H3/b4-3+/t13-,14-,17-,18-,19+,20-,21+,22-,23+/m1/s1
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| Chemical Name |
[(2R,3S,4S,5R,6R)-6-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (182.32 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.56 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.56 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (4.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8232 mL | 9.1159 mL | 18.2319 mL | |
| 5 mM | 0.3646 mL | 1.8232 mL | 3.6464 mL | |
| 10 mM | 0.1823 mL | 0.9116 mL | 1.8232 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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