| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| Other Sizes |
| Targets |
Multiple targets including antioxidant enzymes, inflammatory mediators, and cancer cell signaling pathways. Dalbergin, as a neoflavonoid, exhibits antioxidant activity by scavenging free radicals and upregulating antioxidant enzymes. It has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators. The compound shows anticancer activity by inducing apoptosis, inhibiting cell proliferation, and modulating signaling pathways. Its antimicrobial activity has been observed against various bacterial and fungal strains.
|
|---|---|
| ln Vitro |
Dalbergin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticancer activities characteristic of neoflavonoids. It may scavenge free radicals, inhibit the production of inflammatory mediators, and modulate signaling pathways involved in cell proliferation and apoptosis. Its specific in vitro activities depend on the concentrations tested and the assay systems used. Further studies are needed to fully characterize its activity profile.
|
| ln Vivo |
In vivo studies of dalbergin are limited. As a neoflavonoid from Dalbergia species, it may contribute to the pharmacological effects of rosewood extracts, which have been used in traditional medicine. Its antioxidant, anti-inflammatory, and anticancer activities suggest potential benefits in various disease models. Further in vivo studies are needed to characterize its specific pharmacokinetic and pharmacodynamic properties.
|
| Enzyme Assay |
Non-cell-based assays for dalbergin include antioxidant assays such as DPPH radical scavenging, ABTS, and FRAP assays. Anti-inflammatory activity is measured by inhibition of COX-2, LOX, or cytokine production in enzyme assays. Antimicrobial activity is assessed by broth microdilution for MIC determination. Standard analytical methods including HPLC, NMR, and mass spectrometry are used for compound characterization.
|
| Cell Assay |
Cell-based assays for dalbergin use various cell lines to assess its biological activities. Macrophage cell lines (e.g., RAW 264.7) are stimulated with LPS and treated with the compound, and inflammatory mediators in culture supernatant are measured. Cancer cell lines are used for anticancer studies assessing cell viability and apoptosis. Antimicrobial activity is assessed in bacterial or fungal cultures.
|
| Animal Protocol |
In vivo studies of dalbergin are limited. Based on its biological activities, potential animal models include: carrageenan-induced paw edema for anti-inflammatory evaluation; tumor xenograft models for anticancer evaluation; and infection models for antimicrobial evaluation. Standard protocols for these models involve administration of the compound followed by measurement of relevant endpoints.
|
| ADME/Pharmacokinetics |
Metabolism / Metabolites
The known metabolites of 6-hydroxy-7-methoxy-4-phenylcoumarin include 7-methoxy-4-phenylcoumarin and 6-O-glucuronide. Dalbergin has a molecular formula of C₁₆H₁₂O₄ and a molecular weight of approximately 268.26 g/mol. It is a naturally occurring neoflavonoid isolated from Dalbergia species. The compound is soluble in organic solvents such as DMSO and methanol. It should be stored under recommended conditions. It is intended for research use only. |
| Toxicity/Toxicokinetics |
Specific toxicity data for dalbergin are limited. As a natural neoflavonoid, it is generally considered to have low toxicity. Standard laboratory safety practices should be followed when handling this compound, including the use of personal protective equipment. It is intended for research use only.
|
| References | |
| Additional Infomation |
Dalbergia is a novel flavonoid compound. It has been reported to exist in Dalbergia miscolobium, Dalbergia nigra, and other organisms with relevant data.
Dalbergin is a naturally occurring neoflavonoid compound isolated from Dalbergia species (rosewood) and other plants. Neoflavonoids are a class of compounds known for their diverse biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. Dalbergin is used as a reference standard for the identification and quantification of neoflavonoids in plant extracts and for research purposes. It is for research use only. |
| Molecular Formula |
C16H12O4
|
|---|---|
| Molecular Weight |
268.26
|
| Exact Mass |
268.073
|
| CAS # |
482-83-7
|
| PubChem CID |
442768
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
489.0±45.0 °C at 760 mmHg
|
| Melting Point |
210ºC
|
| Flash Point |
187.5±22.2 °C
|
| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.641
|
| LogP |
3.34
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
20
|
| Complexity |
397
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
COC1=C(C=C2C(=CC(=O)OC2=C1)C3=CC=CC=C3)O
|
| InChi Key |
AZELSOYQOIUPBZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H12O4/c1-19-15-9-14-12(7-13(15)17)11(8-16(18)20-14)10-5-3-2-4-6-10/h2-9,17H,1H3
|
| Chemical Name |
6-hydroxy-7-methoxy-4-phenylchromen-2-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (372.77 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.32 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7277 mL | 18.6386 mL | 37.2773 mL | |
| 5 mM | 0.7455 mL | 3.7277 mL | 7.4555 mL | |
| 10 mM | 0.3728 mL | 1.8639 mL | 3.7277 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
