| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| ln Vitro |
TEAD1/3/4-IN-1 (compound 1) (0-20 μM, 6 days) inhibited the proliferation of NCI-H226 cells with an IC50 of 7 nM[1].
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|---|---|
| ln Vivo |
TEAD1/3/4-IN-1 (compound 1) (10-50 mg/kg, orally, once daily for 45 days) showed significant anticancer activity in a mouse model of squamous cell carcinoma of the lung [1].
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| Animal Protocol |
Animal/Disease Models:NCI-H226 lung squamous cell carcinoma xenograft model established in female BALB/c nude mice (6-7 weeks old) [1]
Doses: 10 and 50 mg/kg Route of Administration: Oral (po), once daily for 45 days Experimental Results: Significant antitumor activity was observed, with TGI values of 109% and 111% in the 10 mg/kg and 50 mg/kg groups, respectively. |
| References |
| Molecular Formula |
C18H13F4N5O2
|
|---|---|
| Molecular Weight |
407.32
|
| CAS # |
2762619-63-4
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| Appearance |
Light yellow to yellow solid
|
| SMILES |
O=C(N1CC(C1)N2C(N(C3=NC=CN=C32)C4=CC=C(C(F)(F)F)C=C4)=O)C(F)=C
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~27.5 mg/mL (~67.51 mM; ultrasonic and warming and heat to 60°C)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (6.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (27.5 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4551 mL | 12.2754 mL | 24.5507 mL | |
| 5 mM | 0.4910 mL | 2.4551 mL | 4.9101 mL | |
| 10 mM | 0.2455 mL | 1.2275 mL | 2.4551 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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