| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| ln Vitro |
TD034 at a concentration of 2 μM significantly increased the level of SHMT2 fatty acid acylation in HEK293T cells[1]. TD034 (5-10 μM) significantly reduced the level of YAP1 protein in A549 cells and reduced the mRNA levels of two YAP1 target genes, CTGF and CYR61[1].
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| References |
| Molecular Formula |
C45H64N4O6
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|---|---|
| Molecular Weight |
757.01
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| CAS # |
3030718-42-1
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| Appearance |
Off-white to light yellow solid
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| SMILES |
CCCCCCCCCCC[C@@H]1[C@H](O1)C(CCCCC[C@@H]2NC([C@]3([H])N(CCCC3)C([C@@H](NC([C@@H](NC2=O)CC4=CC=CC=C4)=O)CC5=CC=CC=C5)=O)=O)=O
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: 本产品在运输和储存过程中需避光（避免光照）。 |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~132.10 mM; with sonication)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (6.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3210 mL | 6.6049 mL | 13.2099 mL | |
| 5 mM | 0.2642 mL | 1.3210 mL | 2.6420 mL | |
| 10 mM | 0.1321 mL | 0.6605 mL | 1.3210 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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