| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 500mg |
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| Other Sizes |
| References |
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| Molecular Formula |
C28H27CLF3N7O3
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|---|---|
| Molecular Weight |
602.01
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| Related CAS # |
Nilotinib-d6; Nilotinib; Nilotinib monohydrochloride monohydrate; Nilotinib (Standard); Nilotinib-13C,d3; Nilotinib monohydrochloride monohydrate (Standard); Nilotinib hydrochloride
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| Appearance |
White to off-white solid
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| SMILES |
O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.O.O.Cl
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| Synonyms |
AMN107 hydrochloride dihydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: 请将本产品存放在密封保护的环境中，避免受潮。 |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~166.11 mM; with sonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (8.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. Solubility in Formulation 2: 10 mg/mL (16.61 mM) in 0.5% HPMC/1% Tween-80 in Saline water (add these co-solvents sequentially from left to right, and one by one), Suspended solution; Need ultrasonic. View More
Solubility in Formulation 3: 5 mg/mL (8.31 mM) in 17% Solutol HS-15 in Saline (add these co-solvents sequentially from left to right, and one by one), Suspended solution; Need ultrasonic. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6611 mL | 8.3055 mL | 16.6110 mL | |
| 5 mM | 0.3322 mL | 1.6611 mL | 3.3222 mL | |
| 10 mM | 0.1661 mL | 0.8306 mL | 1.6611 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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