Prazosin HCl

Alias: cp-12299-1; Prazosin Hydrochloride; Prazosin HCl; Furazosin hydrochloride; cp12299-1; cp 12299-1; Minipress; Peripress; Prazosin
Cat No.:V1137 Purity: ≥98%
Prazosin HCl (Furazosin, cp12299-1; cp-12299-1; Minipress, Peripress), the hydrochloride salt of prazosin, is a potent and competitive alpha-1 adrenoceptor antagonist with antihypertensive effects.
Prazosin HCl Chemical Structure CAS No.: 19237-84-4
Product category: Adrenergic Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
250mg
500mg
1g
2g
5g
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Other Forms of Prazosin HCl:

  • Prazosin
  • Prazosin-d8 (prazosin-d8)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Prazosin HCl (Furazosin, cp12299-1; cp-12299-1; Minipress, Peripress), the hydrochloride salt of prazosin, is a potent and competitive alpha-1 adrenoceptor antagonist with antihypertensive effects. It has been used to treat heart failure, hypertension, pheochromocytoma, Raynaud disease, prostratic hypertrophy, high blood pressure, or benign prostatic hyperplasia (BPH). It has also been used to treat urinary retention. Only in the presence of eNOS does prazosin cause a notable rise in VEGF concentration in endothelial cells and angiogenesis. Prazosin attaches itself to the α1-adrenergic receptors found on the smooth muscle cells encircling all major blood vessels.

Biological Activity I Assay Protocols (From Reference)
Targets
α adrenergic receptor
ln Vitro

In vitro activity: Prazosin only causes angiogenesis and a marked rise in VEGF concentration in endothelial cells when eNOS is present. All larger blood vessels' smooth muscle cells have α1-adrenergic receptors, which are bound by prazosin.[1] Prazosin (0.1 nM) does not considerably lessen the vasomotor effect of exogenous noradrenaline, but it does block the increases in perfusion pressure brought on by electrical stimulation of the perimesenteric nerves.[2]

ln Vivo
Prazosin (0.05-0.20 mg/kg s.c.), a dopamine D2 receptor antagonist, increases the suppression of the conditioned avoidance response when prazosin (0.2 mg kg(-1) s.c.) is administered in rats.[4] In rats that are free to move, the administration of 1 mg/kg of prazosin s.c. consistently lowers rearing but only marginally decreases horizontal activity during the first 10-minute study period. In rats that are free to roam around, prazosin successfully inhibits the locomotor stimulation brought on by either dosage of MK-801.[5]
Animal Protocol
0.5-2.0 mg/kg; s.c.
Rats
References

[1]. Am J Physiol Heart Circ Physiol . 2004 Nov;287(5):H2300-8.

[2]. J Pharmacol Exp Ther . 1997 Aug;282(2):691-8.

[3]. Psychopharmacology (Berl) . 2011 Nov;218(1):89-99.

[4]. J Neural Transm (Vienna) . 2000;107(10):1229-38.

[5]. Eur J Pharmacol . 1996 Aug 1;309(1):1-11.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C19H22CLN5O4
Molecular Weight
419.86
Exact Mass
419.14
Elemental Analysis
C, 54.35; H, 5.28; Cl, 8.44; N, 16.68; O, 15.24
CAS #
19237-84-4
Appearance
White to off-white crystalline powder
SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
InChi Key
WFXFYZULCQKPIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
Chemical Name
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
Synonyms
cp-12299-1; Prazosin Hydrochloride; Prazosin HCl; Furazosin hydrochloride; cp12299-1; cp 12299-1; Minipress; Peripress; Prazosin
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 4~14.3 mg/mL (9.5~34.0 mM)
Water: ~<1 mg/mL
Ethanol: ~<1 mg/mL
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.3817 mL 11.9087 mL 23.8175 mL
5 mM 0.4763 mL 2.3817 mL 4.7635 mL
10 mM 0.2382 mL 1.1909 mL 2.3817 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02965027 Active
Recruiting
Drug: Prazosin
Drug: Placebos
Post-Traumatic Headache Seattle Institute for Biomedical
and Clinical Research
November 29, 2016 Phase 4
NCT04793685 Recruiting Drug: Prazosin
Behavioral: 12-Step Facilitation
with Relapse Prevention and
Contingency Management
Alcohol Withdrawal Yale University July 1, 2021 Phase 1
Phase 2
NCT03539614 Recruiting Drug: Prazosin
Drug: Placebo
Posttraumatic Stress Disorder VA Office of Research andCDevelopment June 4, 2018 Phase 3
NCT04721353 Recruiting Drug: Prazosin Hydrochloride Cannabis Dependence
Cannabis Use Disorder
VA Puget Sound Health Care
System
November 9, 2020 Phase 4
NCT06147622 Not yet recruiting Drug: KT110
Drug: Prazosin + cyproheptadine
Alcohol Use Disorder Kinnov Therapeutics February 2024 Phase 1
Biological Data
  • Effect of prazosin or guanfacine on yohimbine-induced reinstatement and effect of prazosin on intermittent footshock-induced reinstatement. Psychopharmacology (Berl) . 2011 Nov;218(1):89-99.
  • Effect of prazosin or guanfacine on food-reinforced responding. Psychopharmacology (Berl) . 2011 Nov;218(1):89-99.
  • Upregulation of eNOS in skeletal muscles of C57BL/6 mice in response to prazosin. Am J Physiol Heart Circ Physiol . 2004 Nov;287(5):H2300-8.
  • Quantification of VEGF in EDL muscle homogenates of C57BL/6 mice and eNOS-knockout mice during 14 days of prazosin administration. Am J Physiol Heart Circ Physiol . 2004 Nov;287(5):H2300-8.
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