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      Prazosin HCl
      Prazosin HCl

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1137
      CAS #: 19237-84-4 Purity ≥98%

      Description: Prazosin HCl (Furazosin, cp12299-1; cp-12299-1; Minipress, Peripress), the hydrochloride salt of prazosin, is a potent and competitive alpha-1 adrenoceptor antagonist with antihypertensive effects. It has been used to treat high blood pressure or BPH-benign prostatic hyperplasia, heart failure, hypertension, pheochromocytoma, Raynaud disease, prostratic hypertrophy and urinary retention. Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels.

      References: Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2300-8; Psychopharmacology (Berl). 2011 Nov;218(1): 89-99. 

      Related CAS#：19216-56-9 (free)

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      Molecular Weight (MW)419.86 
      FormulaC19H21N5O4·HCl 
      CAS No.19237-84-4 (HCl); 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 4 mg/mL (9.52 mM) 
      Water: <1 mg/mL
      Ethanol: <1 mg/mL
      Other infoChemical Name: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
      InChi Key: WFXFYZULCQKPIP-UHFFFAOYSA-N
      InChi Code: InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
      SMILES Code: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
      Synonymscp-12299-1; Prazosin Hydrochloride, Prazosin HCl, Furazosin hydrochloride, cp12299-1; cp 12299-1; Minipress, Peripress, Prazosin


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      In Vitro

      In vitro activity: Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels. Prazosin (0.1 nM) blocks the increases in perfusion pressure caused by electrical stimulation of the perimesenteric nerves but does not significantly reduce the vasomotor effect of exogenous noradrenaline.

      In VivoPrazosin application leads to the expansion of the capillary system by modulation of the hemodynamic environment (flow rate, shear stress) in skeletal muscle. Prazosin induces angiogenesis in extensor digitorum longus (EDL) muscles of C57BL/6 mice but not eNOS-knockout mice. Prazosin (0.5-2.0 mg/kg) blocks Yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking in rats. Prazosin (0.2mg kg(-1) s.c.) causes an enhancement of a suppression of conditioned avoidance response in the presence of the dopamine D2 receptor antagonist raclopride (0.05-0.20 mg/kg s.c.) in rats. Prazosin administration alone (1 mg/kg, s.c.) only slightly reduces horizontal activity during an initial 10 min measurement period, although it consistently reduces rearing in freely moving rats. Prazosin effectively suppresses the locomotor stimulation caused by either dose of MK-801 throughout the whole observation period in freely moving rats. 
      Animal modelRats
      Formulation & Dosage0.5-2.0 mg/kg; s.c.
      ReferencesAm J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2300-8; Psychopharmacology (Berl). 2011 Nov;218(1):89-99.  

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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