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    Pradigastat (LCQ-908)
    Pradigastat (LCQ-908)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4537
    CAS #: 956136-95-1Purity ≥98%

    Description: Pradigastat (formerly also known as LCQ-908) is a novel, potent and orally bioavailable diacylglycerol acyltransferase 1 (DGAT1) inhibitor being developed for the treatment of familial chylomicronemia syndrome. Familial chylomicronemia syndrome (FCS) is a rare lipid disease caused by complete lipoprotein lipase (LPL) deficiency resulting in fasting chylomicronemia and severe hypertriglyceridemia. Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS .

    References:  2010 Jul;13(4):489-96.


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    Pradigastat

    Name: Pradigastat (LCQ-908)
    CAS#: 956136-95-1
    Chemical Formula: C25H24F3N3O2
    Exact Mass: 455.18206
    Molecular Weight: 455.48121
    Elemental Analysis: C, 65.92; H, 5.31; F, 12.51; N, 9.23; O, 7.03
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: LCQ-908; LCQ908; LCQ 908
    IUPAC/Chemical Name: 2-((1s,4s)-4-(4-(5-((6-(trifluoromethyl)pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexyl)acetic acid
    InChi Key: GXALXAKNHIROPE-CALCHBBNSA-N
    InChi Code: InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)/t16-,17+
    SMILES Code: FC(F)(C1=NC=C(NC2=CN=C(C3=CC=C([[email protected]](CC4)CC[[email protected]]4CC(O)=O)C=C3)C=C2)C=C1)F


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