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    PIK-293 (IC-87114)
    PIK-293 (IC-87114)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0140
    CAS #: 900185-01-5Purity ≥98%

    Description:PIK-293 (IC87114), the parent compound of PIK-294, is a novel, potent, and the first isoform-selective PI3K (phosphatidylinositol 3-kinase) inhibitor with with potential anticancer activity. It inhibits PI3Kδ with an IC50 of 0.24 μM, and is 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. 

    References:  Knight ZA et al. Cell, 2006, 125(4), 733-747.

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    Molecular Weight (MW)

    397.43

    Formula

    C22H19N7O

    CAS No.

    900185-01-5

    Storage

    -20℃ for 3 years in powder form

    -80℃ for 2 years in solvent

    Solubility (In vitro)

    DMSO: 80 mg/mL (201.3 mM)

    Water:<1 mg/mL

    Ethanol: <1 mg/mL

    Other info

    InChi Key: KQDBVHKNIYROHU-UHFFFAOYSA-N
    InChi Code: InChI=1S/C22H19N7O/c1-13-6-3-4-9-17(13)29-18(27-16-8-5-7-14(2)19(16)22(29)30)11-28-21-15(10-26-28)20(23)24-12-25-21/h3-10,12H,11H2,1-2H3,(H2,23,24,25)
    SMILES Code: O=C1N(C2=CC=CC=C2C)C(CN3N=CC4=C(N)N=CN=C43)=NC5=C1C(C)=CC=C5

    Chemical Name

    2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; PIK-293; PIK 293; PIK293


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    In Vitro

    Kinase Assay: PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. PIK-293 inhibits the p110α, p110β, p110δ, and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM,and 10 &kkkmu;M. PIK-293 is the parent compound of PIK-294. 

     

    Cell Assay: PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine.

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    References

    [1] Knight ZA et al. Cell, 2006, 125(4), 733-747.


    These protocols are for reference only. InvivoChem does not independently validate these methods.


     
    PIK-293
    Probing the Selectivity and Affinity Pockets. Cell, 2006, 125(4), 733-747.





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