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    Pifithrin-β (QB-102 and Cyclic-Pifithrin-α)
    Pifithrin-β (QB-102 and Cyclic-Pifithrin-α)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0091
    CAS #: 60477-34-1Purity ≥98%

    Description: Pifithrin-β (also known as QB102 and Cyclic-Pifithrin-α) is a novel and potent p53 inhibitor with an IC50 of 23 μM. It is a cell-permeable analog of Pifithrin-α but with higher stability and reduced cytotoxicity. Pifithrin-β has neuroprotective activity by counteracting the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. The p53 is encoded in humans by the TP53 gene. The molecular mass of p53 is 53 KD. The p53 has the function of regulating the cell cycle, thus, it functions as preventing cancer, a tumor suppressor. The p53 plays an important role in apoptosis, inhibition of angiogenesis and genomic stability by activating DNA repair proteins, arresting cell growth though holding the cell cycle and initiating apoptosis. p53 becomes activated in response to DNA damage, osmotic shock, oxidative stress or other myriad stressors. Activated p53 activates the expression of several genes by binding DNA including p21.

    References:  2011 Mar 1;19(5):1649-57; . 2014 May 21; 5(5): 390–399.

    Related CAS: 511296-88-1 (HBr); 2109248-93-1 (HCl)  

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    Molecular Weight (MW)268.38
    FormulaC₁₆H₁₆N₂S  
    CAS No.60477-34-1 (free base); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 10 mM
    Water:  N/A
    Ethanol: N/A
    SynonymsPifithrin-β; PFTβ; Pifithrin-beta; QB102; QB 102; QB-102; PFT-β; Cyclic-Pifithrin-α


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    Pifithrin-β


    NAC increased the level of p53 target gene transcription. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β


    NAC treatment induced cell cycle arrest. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β


    NAC induced apoptotic cell death. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β


    Cytotoxic effects of the tested compounds and pifithrin-β at 1 (A) and 10 μM (B) on SH-SY5Y cells. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β


    Neuroprotective effects of compounds 4, 12, and 19.  . 2014 May 21; 5(5): 390–399.

     Pifithrin-β


    (A) Concentration–response curves of compound 12 and pifithrin-β. . 2014 May 21; 5(5): 3


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