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    Pifithrin-β HBr (QB102; Cyclic Pifithrin-α)
    Pifithrin-β HBr (QB102; Cyclic Pifithrin-α)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0092
    CAS #: 511296-88-1Purity ≥98%

    Description: Pifithrin-β HBr (QB-102; Cyclic-Pifithrin-α), the hydrobromide salt of Pifithrin-β, is a potent p53 inhibitor (IC50 of 23 μM) and a cell-permeable Cyclized analog of Pifithrin-α with higher stability and reduced cytotoxicity. Pifithrin-β HBr has neuroprotective activity. 

    References:  2011 Mar 1;19(5):1649-57; . 2014 May 21; 5(5): 390–399.

    Related CAS: 60477-34-1 (free base);  2109248-93-1 (HCl)

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    Molecular Weight (MW)349.29
    FormulaC16H17BrN2S   
    CAS No.511296-88-1 (HBr); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: >10 mM
    Water:  N/A
    Ethanol: N/A
    SynonymsPifithrin-β HBr; Pifithrin-beta HBr; PFTβ HBr; PFT-β HBr; QB102 HBr; QB 102; QB-102; Cyclic-Pifithrin-α


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    These protocols are for reference only. InvivoChem does not independently validate these methods.

     Pifithrin-β HBr


    NAC increased the level of p53 target gene transcription. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β HBr


    NAC treatment induced cell cycle arrest. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β HBr


    NAC induced apoptotic cell death. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β HBr


    Cytotoxic effects of the tested compounds and pifithrin-β at 1 (A) and 10 μM (B) on SH-SY5Y cells. . 2014 May 21; 5(5): 390–399.

     Pifithrin-β HBr


    Neuroprotective effects of compounds 4, 12, and 19.  . 2014 May 21; 5(5): 390–399.

     Pifithrin-β HBr


    (A) Concentration–response curves of compound 12 and pifithrin-β. . 2014 May 21; 5(5): 390–


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