| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| ln Vivo |
In comparison to the control, topical administration of 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4), and 0.5% CDV significantly reduced the number of Ad-positive cultures and their entire length (days 1–14). The Ad5/NZW rabbit eye model's advertising shedding. The effectiveness of picolinic acid on the length of AD shedding appeared to follow a concentration-dependent pattern, however it was not statistically significant. Concentrations of picolinic acid do not cause any appreciable ocular toxicity [1].
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| References | |
| Additional Infomation |
Picolinic acid is a pyridine monocarboxylic acid with its carboxyl group at the 2-position. It is an intermediate in tryptophan metabolism. It serves as a matrix material for MALDI and is also a human metabolite. It is the conjugate acid of Picolinic acid esters. PCL-016, or Picolinic acid, is the active pharmaceutical ingredient of tryptophan, a Picolinic acid metabolite. It possesses anti-infective and immunomodulatory effects, with approximately 25-50 mg produced daily by the human body through the breakdown of tryptophan. PCL-016 plays a crucial role in zinc transport. As a therapeutic agent, this molecule inhibits the function of zinc finger proteins (ZFPs) by binding to them, altering their structure, and disrupting zinc binding. ZFPs are involved in viral replication and packaging, as well as normal cellular homeostasis. Picolinic acid has been shown to possess antiviral activity both in vitro and in vivo, sometimes synergistically with other cytokines (such as interferon-gamma) to influence immune responses. Therefore, acne vulgaris, herpes, and other viral infections are potential therapeutic targets for PCL-016.
Picolinic acid has been reported to be found in Fusarium lateritium, Aloe africana, and other organisms with relevant data. See also: Nicotinamide (note moved to) Picolinic acid (note moved to). Drug Indications It has been studied for the treatment of acne, cold sores (herpes labialis), and sexually transmitted diseases. Mechanism of Action As a therapeutic agent, this molecule inhibits the function of zinc finger proteins (ZFPs) by binding to them, altering their structure, and disrupting zinc binding. Pharmacodynamics PCL-016, or Picolinic acid, is a Picolinic acid metabolite of tryptophan. It exerts its anti-infective and immunomodulatory effects by participating in zinc transport. ZFPs are involved in viral replication and packaging, as well as normal cellular homeostasis. Both in vitro and in vivo studies have demonstrated that Picolinic acid possesses antiviral activity. |
| Molecular Formula |
C6H5NO2
|
|---|---|
| Molecular Weight |
123.11
|
| Exact Mass |
123.032
|
| CAS # |
98-98-6
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| Related CAS # |
Picolinic acid-d4;284487-61-2
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| PubChem CID |
1018
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| Appearance |
White to off-white solid powder
|
| Density |
1.3±0.1 g/cm3
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| Boiling Point |
292.5±13.0 °C at 760 mmHg
|
| Melting Point |
139-142 °C(lit.)
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| Flash Point |
130.7±19.8 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.571
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| LogP |
-0.1
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
9
|
| Complexity |
114
|
| Defined Atom Stereocenter Count |
0
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| InChi Key |
SIOXPEMLGUPBBT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
|
| Chemical Name |
pyridine-2-carboxylic acid
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| Synonyms |
PCL-016; NVTL-0001; NV-02
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~812.28 mM)
H2O : ≥ 50 mg/mL (~406.14 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (20.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (20.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (20.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (812.28 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.1228 mL | 40.6141 mL | 81.2282 mL | |
| 5 mM | 1.6246 mL | 8.1228 mL | 16.2456 mL | |
| 10 mM | 0.8123 mL | 4.0614 mL | 8.1228 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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