| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
| Targets |
Phytic acid acts as a chelator of multivalent metal ions, particularly zinc (Zn²⁺), calcium (Ca²⁺), and iron (Fe²⁺/Fe³⁺). It forms insoluble complexes with these ions, affecting their bioavailability. No specific IC₅₀, Kᵢ, or EC₅₀ values for individual targets are provided in the literature. [1]
Phytic acid may also influence intracellular signaling pathways through its lower phosphorylated metabolites (e.g., inositol trisphosphate, InsP₃), which act as second messengers in calcium mobilization. [1] |
|---|---|
| ln Vitro |
Sodium phytate hydrate (inositol) inhibits the production of uric acid from xanthine with an IC50 of around 30 mM. Dodecasodium phytate hydrate has a stronger impact on the formation of superoxide; the IC50 is about 6 mM, indicating that the superoxide generating domain of XO is more susceptible to phytic acid [3].
Phytic acid inhibits iron-catalyzed hydroxyl radical formation and lipid peroxidation in vitro, demonstrating antioxidant properties. [1] Phytic acid suppresses the growth and differentiation of K-562 human erythroleukemia cells and HT-29 colon adenocarcinoma cells. [1] Phytic acid reduces ascorbic acid degradation and lipid peroxidation in food systems, suggesting potential as a natural food preservative. [1] |
| ln Vivo |
Dietary phytic acid (1–2% in drinking water) suppresses large intestinal cancer in F344 rats and CD-1 mice, both before and after carcinogen induction. The inhibitory effect is dose-dependent. [1]
Phytic acid lowers serum cholesterol and triglycerides in rats, likely through modulation of zinc and copper absorption and reduction of the serum zinc/copper ratio. [1] Phytic acid reduces renal stone formation in patients with hypercalciuria when consumed in a rice bran-containing diet over 1–3 years. [1] Intraperitoneal injection of phytic acid inhibits growth of subcutaneously transplanted fibrosarcoma in mice, prolongs survival, and reduces pulmonary metastases. [1] |
| Cell Assay |
Phytic acid inhibits the growth and induces differentiation of K-562 erythroleukemia cells and HT-29 colon adenocarcinoma cells in culture. Specific concentrations and assay conditions are not detailed. [1]
Phytic acid enhances natural killer (NK) cell activity in mouse and human cell systems, correlating with tumor suppression in experimental models. [1] |
| Animal Protocol |
In carcinogenesis studies, phytic acid is administered in drinking water at 1–2% concentration to F344 rats or CD-1 mice, both before and after induction with carcinogens such as azoxymethane. [1]
For cholesterol-lowering studies, phytic acid is supplemented in the diet of rats, resulting in reduced serum cholesterol and triglycerides. [1] In renal stone prevention studies, patients consume a rice bran-rich diet (containing phytic acid) for 1–3 years, leading to reduced urinary calcium excretion and kidney stone incidence. [1] In antitumor studies, phytic acid is administered intraperitoneally to mice bearing transplanted fibrosarcoma, resulting in reduced tumor growth and metastasis. [1] |
| ADME/Pharmacokinetics |
Phytic acid is hydrolyzed in the gastrointestinal tract by dietary plant phytase, bacterial flora phytase, and possibly intestinal mucosal phytase to produce hypophosphorylated inositol phosphate and inositol. [1] In rats, ³H-labeled phytic acid administered by gavage is rapidly absorbed by the upper digestive tract, dephosphorylated to inositol and inositol monophosphate, and distributed in various tissues. [1] Dietary calcium levels affect phytic acid absorption: low calcium intake increases phytic acid absorption, while high calcium intake decreases it. [1]
|
| Toxicity/Toxicokinetics |
High dietary phytic acid (1-2% in drinking water) may reduce the bioavailability of minerals, leading to slower growth, lower serum mineral (zinc, calcium, iron) levels, and impaired immune function in animals. [1]
Rats fed diets containing 2-2.5% phytic acid had an increased incidence of renal papilloma and ultimately a decrease in body weight. [1] One study found that adding 1% phytic acid to drinking water had no significant effect on serum mineral (Mg²⁺, Ca²⁺, Fe²⁺, Zn²⁺) levels and weight gain, but the sample size was small (3-5 rats per group). [1] |
| References | |
| Additional Infomation |
Phytic acid is the main phosphorus storage compound in seeds and cereals, accounting for 1% to 7% of dry weight and more than 70% of total phosphorus content in grains. [1]
Because of its strong chelating ability with minerals, it reduces the bioavailability of zinc, iron and calcium, and is therefore considered an anti-nutritional substance. [1] Potential health benefits include antioxidant activity, reduced risk of colon cancer, prevention of kidney stones and regulation of blood lipids. [1] Pytic acid may serve as a precursor to second messengers (e.g., InsP₃) in intracellular calcium signaling. [1] Human studies on phytic acid supplementation are limited, and its use in people with mineral malnutrition is not recommended until further research is conducted. [1] |
| Molecular Formula |
C6H8NA12O25P6
|
|---|---|
| Molecular Weight |
941.8325
|
| Exact Mass |
941.655
|
| CAS # |
123408-98-0
|
| Related CAS # |
Phytic acid;83-86-3;Calcium Phytate;3615-82-5
|
| PubChem CID |
56845531
|
| Appearance |
White to off-white solid powder
|
| LogP |
2.061
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
25
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
49
|
| Complexity |
749
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
IHFMYFHNGBHKCG-UHFFFAOYSA-B
|
| InChi Code |
InChI=1S/C6H18O24P6.12Na.H2O/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;;1H2/q;12*+1;/p-12
|
| Chemical Name |
dodecasodium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate;hydrate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 250 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0618 mL | 5.3088 mL | 10.6176 mL | |
| 5 mM | 0.2124 mL | 1.0618 mL | 2.1235 mL | |
| 10 mM | 0.1062 mL | 0.5309 mL | 1.0618 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
