Size | Price | Stock | Qty |
---|---|---|---|
25mg |
|
||
50mg |
|
||
100mg |
|
||
250mg |
|
||
500mg |
|
||
1g |
|
||
Other Sizes |
|
Purity: ≥98%
Phenprocoumon (Marcumar), a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K, is a vitamin K reductase with an IC50 of 1 μM. Phenprocoumon inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders.
ln Vivo |
The anticoagulant effect of a single intravenous injection of 0.355 mg/kg was higher in older rats than in younger rats. The elimination rate, volume of distribution, free fraction, and free concentration values of phenprocoumon in plasma and liver were not different in old and young rats. The concentration of [3H]vitamin K1 in the liver decreased after an intravenous injection of 64.3 μg/kg and different doses of phenprocoumon (0.02 to 3 mg/kg), and [3H]vitamin K1-2, 3 -The increase in epoxide concentration depends on the phenprocoumon dose and hepatic concentrations. These changes are more noticeable in older rats than in younger rats [2].
|
---|---|
References |
[1]. Straubhaar B, et al. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. 2006;29(1):79-90.
[2]. DIETMAR TRENK, et al. Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. Trenk D. J Pharm Pharmacol. 1980 Dec;32(12):828-32. |
Molecular Formula |
C18H16O3
|
---|---|
Molecular Weight |
280.31784
|
CAS # |
435-97-2
|
Related CAS # |
152-72-7 (Acenocoumarol); 82-66-6 (Diphenadione); 15301-97-0 ( 15301-97-0); 81-81-2 (Warfarin; WARF42; Athrombine-K); 5543-57-7 [(S)-Warfarin]; 81-81-2 (Warfarin); 129-06-6 (Warfarin sodium); 81-82-3 (Coumachlor); 5836-29-3 ( Coumatetralyl; Endox; Racumin; Endrocide); 518-20-7 (Actosin, Anticoagulans 63, BL 5, Compound 63 link, Cumopyran, Cumopyrin, Cyclocoumarol, Cyclocumarol, Methanopyranorin, Pyranocoumarin, Pyranocumarin); 66-76-2 (Dicumarol)
|
SMILES |
CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O
|
InChi Key |
DQDAYGNAKTZFIW-UHFFFAOYSA-N
|
InChi Code |
InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3
|
Chemical Name |
4-hydroxy-3-(1-phenylpropyl)chromen-2-one
|
Synonyms |
Marcoumar, Marcumar and Falithrom; Phenprocoumon; Phenprocoumarol; Marcumar; Phenprocoumarole; Falithrom
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : ≥ 125 mg/mL (~445.92 mM)
|
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.42 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.42 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.42 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5674 mL | 17.8368 mL | 35.6735 mL | |
5 mM | 0.7135 mL | 3.5674 mL | 7.1347 mL | |
10 mM | 0.3567 mL | 1.7837 mL | 3.5674 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.