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    PF06650833
    PF06650833

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4562
    CAS #: 1817626-54-2Purity ≥98%

    Description: PF06650833 is a novel, potent and selective inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4) which is used to treat autoimmune diseases such as rheumatoid arthritis, lupus, and lymphomas. RAK4 is located proximal to TLR/IL-1 receptors, and in preclinical studies, inhibits downstream signaling from these receptors. The development of novel small molecule inhibitors of this kinase has the potential to lead to new therapeutics to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.

    References:  2016 Aug;26(8):917-32. 


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    PF06650833

    Name: PF-06650833
    CAS#: 1817626-54-2
    Chemical Formula: C18H20FN3O4
    Exact Mass: 361.1438
    Molecular Weight: 361.3734
    Elemental Analysis: C, 59.83; H, 5.58; F, 5.26; N, 11.63; O, 17.71
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-06650833; PF 06650833; PF06650833; PF-6650833; PF 6650833; PF6650833.
    IUPAC/Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
    InChi Key: JKDGKIBAOAFRPJ-ZBINZKHDSA-N
    InChi Code: InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1
    SMILES Code: O=C(C1=CC2=C(C(OC[[email protected]]([[email protected]](CC)[[email protected]@H]3F)NC3=O)=NC=C2)C=C1OC)N


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