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    PF-04979064
    PF-04979064

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4430
    CAS #: 1220699-06-8 Purity ≥98%

    Description: PF-04979064 is a novel, potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. PI3K, AKT, and mTOR are key kinases from PI3K signaling pathway being extensively pursued to treat a variety of cancers in oncology. To search for a structurally differentiated back-up candidate to PF-04691502, which is currently in phase I/II clinical trials for treating solid tumors, a lead optimization effort was carried out with a tricyclic imidazo[1,5]naphthyridine series. Integration of structure-based drug design and physical properties-based optimization yielded a potent and selective PI3K/mTOR dual kinase inhibitor PF-04979064.  

    References:  2012 Nov 7;4(1):91-7. 


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    PF-04979064

    Name: PF-04979064
    CAS#: 1220699-06-8
    Chemical Formula: C24H26N6O3
    Exact Mass: 446.2066
    Molecular Weight: 446.51
    Elemental Analysis: C, 64.56; H, 5.87; N, 18.82; O, 10.75
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-04979064; PF 04979064; PF04979064.
    IUPAC/Chemical Name: 2H-Imidazo(4,5-C)(1,5)naphthyridin-2-one, 1,3-dihydro-1-(1-((2S)-2-hydroxy-1-oxopropyl)-4-piperidinyl)-3-methyl-8-(6-methyl-3-pyridinyl)-
    InChi Key: GACQNUHFDBEIQH-HNNXBMFYSA-N
    InChi Code: InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1
    SMILES Code: O=C(N1C2CCN(C([[email protected]@H](O)C)=O)CC2)N(C)C3=C1C4=NC(C5=CC=C(C)N=C5)=CC=C4N=C3


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