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Penicillin G potassium salt is a salt of Penicillin G which is a hydrophobic, fast-acting β-lactam antibiotic produced by Penicillium spp. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to Penicillin G. In acid aqueous solutions, Penicillin is reported to decompose into penillic acid and penilloic acid.
| References |
: Yang CJ, Tang HJ, Chang SY, Hsieh SM, Lee KY, Lee YT, Sheng WH, Yang SP, Hung
CC, Chang SC. Comparison of serological responses to single-dose azithromycin (2
g) versus benzathine penicillin G in the treatment of early syphilis in
HIV-infected patients in an area of low prevalence of macrolide-resistant
Treponema pallidum infection. J Antimicrob Chemother. 2016 Mar;71(3):775-82.
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| Additional Infomation |
Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).
Penicillin G (potassium or sodium) is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain serious bacterial infections, such as pneumonia, meningitis, gonorrhea, syphilis, and others. Pneumonia and syphilis can be opportunistic infections (OI) of HIV. Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis. A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission. See also: Penicillin G (has active moiety). |
| Molecular Formula |
C16H17KN2O4S
|
|---|---|
| Molecular Weight |
372.4805
|
| Exact Mass |
372.054
|
| Elemental Analysis |
333.09
|
| CAS # |
113-98-4
|
| Related CAS # |
Penicillin G sodium salt;69-57-8;Penicillin G procaine hydrate;6130-64-9;Penicillin G benzathine;1538-09-6;Penicillin G benzathine tetrahydrate;41372-02-5;Penicillin G-d5 potassium;Penicillin G;61-33-6
|
| PubChem CID |
23664709
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
214-217 ℃
|
| Index of Refraction |
294 ° (C=1， H2O)
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
24
|
| Complexity |
536
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
[K+].S1C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(C(=O)[O-])N2C([C@]([H])([C@@]12[H])N([H])C(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)=O
|
| InChi Key |
IYNDLOXRXUOGIU-LQDWTQKMSA-M
|
| InChi Code |
InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
|
| Chemical Name |
potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
|
| Synonyms |
Penicillin G Potassium Salt; Benzylpenicillin
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| HS Tariff Code |
2941.10.2000
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product is not stable in solution, please use freshly prepared working solution for optimal results. (2). Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~268.47 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (268.47 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6847 mL | 13.4235 mL | 26.8471 mL | |
| 5 mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | |
| 10 mM | 0.2685 mL | 1.3424 mL | 2.6847 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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