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    Pantoprazole (BY1023)
    Pantoprazole (BY1023)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1637
    CAS #: 102625-70-7Purity ≥98%

    Description: Pantoprazole (BY1023; SKF96022; Protonix), an anti-ulcer drug, is a proton pump inhibitor (PPI) used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. 

    References: Clin Ther. 2000 Nov;22(11):1268-93.

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    Molecular Weight (MW)383.37
    FormulaC16H15F2N3O4S
    CAS No.102625-70-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 76 mg/mL (198.2 mM)
    Water:<1 mg/mL
    Ethanol: 76 mg/mL (198.2 mM)
    Other info

    Chemical Name: 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-

    InChi Key: IQPSEEYGBUAQFF-UHFFFAOYSA-N

    InChi Code: InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)

    SMILES Code: O=S(C1=NC2=CC(OC(F)F)=CC=C2N1)CC3=NC=CC(OC)=C3OC

    Synonyms

    BY1023; SKF96022; Protonix; BY 1023; BY-1023; SKF 96022; SKF-96022


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    In Vitro

    In vitro activity: Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori.

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    References

    Clin Ther. 2000 Nov;22(11):1268-93.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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