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    Pancuronium dibromide
    Pancuronium dibromide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1162
    CAS #: 15500-66-0Purity ≥98%

    Description: Pancuronium dibromide (OrgNA97; NA-97; Org NA 97; Pavulon), a neuromuscular relaxant used in euthanasia, is a bis-quaternary steroid and a competitive nicotinic acetylcholine receptor antagonist with an IC50 of 5.5 nM. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate.

    References: Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60.

    Related CAS #: 15500-66-0 (bromide)   16974-53-1 (cation)  22189-36-2 (bromide hydrate) 

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    Molecular Weight (MW)732.67
    FormulaC35H60N2O4.2Br
    CAS No.15500-66-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (136.5 mM)
    Water:100 mg/mL (136.5 mM)  
    Ethanol: 100 mg/mL (136.5 mM)
    Other info

    Chemical Name: 1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium) bromide

    InChi Key: NPIJXCQZLFKBMV-YTGGZNJNSA-L

    InChi Code: InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

    SMILES Code: C[[email protected]@]12[[email protected]@H](OC(C)=O)[[email protected]@H]([N+]3(C)CCCCC3)C[[email protected]@]1([H])[[email protected]]4([H])CC[[email protected]@]5([H])C[[email protected]](OC(C)=O)[[email protected]@H]([N+]6(C)CCCCC6)C[[email protected]]5(C)[[email protected]@]4([H])CC2.[Br-].[Br-]

    Synonyms

    NA-97; Org-NA-97; NA97; OrgNA97; NA 97; Org NA 97; Pavulon


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    In Vitro

    In vitro activity: Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.

    In VivoPancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM  in tracheal smooth muscle strips from guinea-pigs.
    Animal modelguinea-pig
    Formulation & DosageNA
    References

    Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Pancuronium dibromide
    The effects of (A) pancuronium (10–9–10–5 M), (B) vecuronium (10–9–10–5 M), (C) rocuronium (10–9–10–5 M), and (D) mivacurium (10–9–10–5 M) on heart rate. Curr Ther Res Clin Exp. 2011 Oct; 72(5): 195–203.
     

    Pancuronium dibromide

    The effects of (A) pancuronium (10–9–10–5 M), (B) vecuronium (10–9–10–5 M), (C) rocuronium (10–9–10–5 M), and (D) mivacurium (10–9–10–5 M) on developed force at rat atrial tissue. Curr Ther Res Clin Exp. 2011 Oct; 72(5): 195–203.


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