| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
||
| 1g |
|
||
| 2g |
|
||
| 5g |
|
||
| 10g |
|
||
| 25g |
|
||
| Other Sizes |
|
Purity: ≥98%
Oxytetracycline (Lenocycline; Oxyterracine; Oxyterracyne; Tarosin; Oxymykoin) is a naturally occurring tetracycline class of antibiotic extracted from the actinomycete STREPTOMYCES rimosus with a broad-spectrum of antibacterial effects. It has been used in a wide variety of clinical conditions for Gram-negative and Gram-positive bacteria. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers. Oxytetracycline therefore stops the spread of the infection and the remaining bacteria are killed by the immune system or eventually die. Oxytetracycline is a broad-spectrum antibiotic, active against a wide variety of bacteria. However, some strains of bacteria have developed resistance to this antibiotic, which has reduced its effectiveness for treating some types of infections.
| ln Vitro |
Oxytetracycline is an essential member of the bacterial aromatic polyketide family and a class of natural compounds with different structures. Oxytetracycline is synthesized by type II polyketide synthase, which generates a poly-β-ketone backbone through sequential decarboxylation condensation of malonyl-CoA extension units, which is then processed by cyclases, oxygenases, transferases, and other tailoring enzymes modification[2].
|
|---|---|
| ln Vivo |
In different animals, oxytetracycline therapeutic doses (82.8 mg/kg body weight to 1% body weight/day) had different effects after 10 days. Morone Chrysops had a higher relative liver weight when given oxytetracycline. There are limits of 100 μg/kg for oxytetracycline in milk and muscle, 200 μg in eggs, 300 μg in liver, and 600 μg in kidneys. Fish receiving therapeutic feed containing 35–75 mg of oxytetracycline (OTC) per kilogram of biomass are given the medication on day 1 and for a duration of 7–14 days [1].
|
| References |
[1]. Elia, A.C., et al., Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem, 2014.
[2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15. [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8. |
| Molecular Formula |
C22H24N2O9
|
|---|---|
| Molecular Weight |
460.4340
|
| CAS # |
79-57-2
|
| Related CAS # |
Oxytetracycline hydrochloride;2058-46-0;Oxytetracycline dihydrate;6153-64-6;Oxytetracycline calcium;7179-50-2
|
| SMILES |
O([H])[C@@]1([H])[C@@]2([H])C(=C(C3C(=C([H])C([H])=C([H])C=3[C@@]2(C([H])([H])[H])O[H])O[H])O[H])C([C@@]2(C(=C(C(N([H])[H])=O)C([C@]([H])([C@]12[H])N(C([H])([H])[H])C([H])([H])[H])=O)O[H])O[H])=O
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 50 mg/mL (~108.59 mM)
H2O : ~0.67 mg/mL (~1.46 mM) |
|---|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1719 mL | 10.8594 mL | 21.7188 mL | |
| 5 mM | 0.4344 mL | 2.1719 mL | 4.3438 mL | |
| 10 mM | 0.2172 mL | 1.0859 mL | 2.1719 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA