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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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Oxytetracycline HCl (Oxymykoin; Oxyterracyne; Oxyterracin; Tarosin; Liquamycin; Oxysteclin), the Hydrochloride salt of Oxytetracycline, is a broad spectrum tetracycline antibiotic with activity against a large number of gram positive and gram negative bacteria. It is a naturally occurring antibiotic isolated from the actinomycete STREPTOMYCES rimosus.
| ln Vitro |
Oxytetracycline is a significant member of the class of naturally occurring products with a variety of structures, as well as the bacterial aromatic polyketide family. Type II polyketide synthase produces a poly-β-ketone backbone by sequentially decarboxylating and condensing of malonyl-CoA extension units. This backbone is further modified by cyclases, oxygenases, transferases, and other tailoring enzymes to produce oxytetracycline[2].
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| ln Vivo |
Different animals respond differently to therapeutic doses of oxytetracycline (82.8 mg/kg body weight to 1% body weight/day) given for 10 days. The oxytetracycline limits are 200 μg/kg in eggs, 300 μg/kg in liver, 600 μg/kg in kidneys, and 100 μg/kg in muscle and milk. Oxytetracycline enhanced the relative liver weight of Morone Chrysops. Fish are fed oxytetracycline (OTC) as medicated feed starting on day 1 and continuing for 7–14 days at doses ranging from 35 to 75 mg ai kg-1 biomass [1].
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| References |
[1]. Elia AC, et al. Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem. 2014 Aug;40(4):1055-68.
[2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15. [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8. |
| Molecular Formula |
C22H25CLN2O9
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|---|---|
| Molecular Weight |
460.4340
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| Elemental Analysis |
C, 53.18; H, 5.07; Cl, 7.13; N, 5.64; O, 28.98
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| CAS # |
2058-46-0
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| Related CAS # |
Oxytetracycline;79-57-2;Oxytetracycline dihydrate;6153-64-6;Oxytetracycline calcium;7179-50-2
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| Appearance |
Light yellow to yellow solid powder.
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| SMILES |
CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O.Cl
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| InChi Key |
SVDOODSCHVSYEK-IFLJXUKPSA-N
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| InChi Code |
InChI=1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)1H/t12-,13-,14+,17+,21-,22+/m1./s1
|
| Chemical Name |
(4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
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| Synonyms |
Oxytetracycline Hydrochloride; Oxytetracycline HCl; Biosolvomycin; Oxytetracycline.HCl; Dalinmycin; Dalimycin; Oxytetracycline, Sodium Salt; Sodium Salt Oxytetracycline; Terramycin;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~99 mg/mL ( ~199.23 mM)
Water : ~99 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 4.17 mg/mL (8.39 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 41.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 4.17 mg/mL (8.39 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 41.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1719 mL | 10.8594 mL | 21.7188 mL | |
| 5 mM | 0.4344 mL | 2.1719 mL | 4.3438 mL | |
| 10 mM | 0.2172 mL | 1.0859 mL | 2.1719 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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